Infectious Diseases department, Centro Hospitalar de São João, Porto, Portugal.
Keypoint Group, Lisbon, Portugal.
HIV Med. 2021 Mar;22(3):212-217. doi: 10.1111/hiv.12963. Epub 2020 Oct 4.
We aimed to characterize neurocognitive impairment (NI) in an HIV-2 population using an observational cross-sectional study in four Portuguese hospitals.
Adult HIV-2-infected patients were included. Montreal Cognitive Assessment Test (MoCA) and International HIV Dementia Scale (IHDS) scales were applied for screening of NI. Patient Health Questionnaire-9 (PHQ-9) and Instrumental Activities of Daily Living (IADL) scales were used for assessment of depression and functionality. A multivariate analysis was performed to assess for risk factors for NI.
Eighty-one patients were included, 50.6% of African origin (n = 41) and 49.4% of Portuguese origin (n = 40). The MoCA scale showed alterations in 81.5% of patients (100% of migrants vs. 62.5% of non-migrants, P < 0.001) and the IHDS scale showed alterations in 42%. Both scales were altered simultaneously in 35.8%. Variables independently associated with NI were age [odds ratio (OR) = 0.885] and migrant status (OR = 9.150).
Neurocognitive impairment (both scales altered) was present in 35.8%, which is comparable to what is described for HIV-1. The MoCA performed worse in the migrant population and might not be applicable in this setting.
我们旨在通过在四家葡萄牙医院进行的观察性横断面研究，描述 HIV-2 人群中的神经认知障碍（NI）。
纳入成年 HIV-2 感染患者。应用蒙特利尔认知评估测试（MoCA）和国际 HIV 痴呆量表（IHDS）量表筛查 NI。采用患者健康问卷-9（PHQ-9）和日常生活活动工具（IADL）量表评估抑郁和功能。进行多变量分析以评估 NI 的危险因素。
共纳入 81 例患者，50.6%（n=41）为非洲裔，49.4%（n=40）为葡萄牙裔。MoCA 量表显示 81.5%的患者（移民患者为 100%，非移民患者为 62.5%，P<0.001）和 IHDS 量表显示 42%的患者存在改变。两种量表同时改变的患者占 35.8%。与 NI 相关的独立变量为年龄[比值比（OR）=0.885]和移民身份（OR=9.150）。
神经认知障碍（两种量表均改变）的发生率为 35.8%，与 HIV-1 描述的情况相当。MoCA 在移民人群中的表现较差，在这种情况下可能不适用。
