UT Southwestern Medical Center, Professional Office Building 1, Suite 520L, 5959 Harry Hines Boulevard, Dallas, TX 75390-8887, USA.
Clin Liver Dis. 2020 Nov;24(4):611-621. doi: 10.1016/j.cld.2020.07.013. Epub 2020 Sep 3.
Patients with cirrhosis of the liver have a very high risk for developing hepatocellular carcinoma (HCC). Therefore, this group of patients should undergo surveillance to improve mortality. Better tools for stratifying the risk of HCC among patients with cirrhosis are needed. The best strategy for surveillance is the combination of alpha-fetoprotein and ultrasound of the liver every 6 months. This strategy shows a sensitivity of approximately 65% and a specificity of 90%, and importantly, has been shown to improve mortality in these patients. Balancing benefits and harms should be performed when deciding to proceed with surveillance.
肝硬化患者发生肝细胞癌（HCC）的风险非常高。因此，这群患者应该接受监测以提高生存率。我们需要更好的工具来对肝硬化患者的 HCC 风险进行分层。最佳的监测策略是每 6 个月进行一次甲胎蛋白和肝脏超声检查。该策略的敏感性约为 65%，特异性为 90%，重要的是，已证明该策略可以改善这些患者的生存率。在决定进行监测时，应该权衡利弊。
