Tianjin Women's and Children's Health Center.
BGI-Shenzhen.
J Epidemiol. 2022 Jan 5;32(1):44-52. doi: 10.2188/jea.JE20200238. Epub 2021 Mar 4.
To investigate the causal link between early-life exposures and long-term health consequences, we established the Tianjin Birth Cohort (TJBC), a large-scale prospective cohort in northern China.
TJBC aims to enroll 10,000 families with follow-ups from pregnancy until children's six year-old. Pregnant women and their spouses were recruited through a three-tier antenatal healthcare system at early pregnancy, with follow-ups at mid-pregnancy, late pregnancy, delivery, 42 days after delivery, 6 months after delivery, and each year until 6 years old. Antenatal/neonatal examination, biological samples and questionnaires were collected.
From August 2017 to January 2019, a total of 3,924 pregnant women have already been enrolled, and 1,697 women have given birth. We observed the prevalence of gestational diabetes mellitus as 18.1%, anemia as 20.4%, and thyroid hypofunction as 2.0%. In singleton live births, 5.6% were preterm birth (PTB), 3.7% were low birth weight, and 7.3% were macrosomia. Based on current data, we also identified maternal/paternal factors which increased the risk of PTB, including paternal age (OR 1.07; 95% CI, 1.01-1.14 for each year increase), vaginal bleeding during pregnancy (OR 2.82; 95% CI, 1.54-5.17) and maternal early-pregnancy BMI (OR 1.08; 95% CI, 1.01-1.15 for each kg/m increase).
TJBC has the strength of collecting comprehensive maternal, paternal, and childhood information. With a diverse range of biological samples, we are also engaging with emerging new technologies for multi-omics research. The study would provide new insight into the causal link between macro/micro-environmental exposures of early life and short/long-term health consequences.
为了探究生命早期暴露与长期健康后果之间的因果关系，我们在中国北方建立了一个大规模的前瞻性队列——天津出生队列（TJBC）。
TJBC 旨在招募 10000 个家庭，从怀孕开始进行随访，直到孩子 6 岁。孕妇及其配偶在妊娠早期通过三级产前保健系统招募，在妊娠中期、妊娠晚期、分娩时、产后 42 天、产后 6 个月以及每年进行随访，直到 6 岁。进行产前/新生儿检查、采集生物样本和问卷调查。
从 2017 年 8 月到 2019 年 1 月，共有 3924 名孕妇入组，其中 1697 名孕妇分娩。我们观察到妊娠期糖尿病的患病率为 18.1%，贫血的患病率为 20.4%，甲状腺功能减退的患病率为 2.0%。在单胎活产中，早产儿（PTB）的比例为 5.6%，低出生体重儿的比例为 3.7%，巨大儿的比例为 7.3%。基于现有数据，我们还确定了增加 PTB 风险的母亲/父亲因素，包括父亲年龄（每增加 1 岁，比值比为 1.07；95%可信区间为 1.01-1.14）、妊娠期间阴道出血（比值比为 2.82；95%可信区间为 1.54-5.17）和母亲孕早期 BMI（每增加 1kg/m，比值比为 1.08；95%可信区间为 1.01-1.15）。
TJBC 具有收集全面的母婴和儿童信息的优势。通过广泛的生物样本，我们还参与了新兴的多组学研究新技术。该研究将为生命早期宏观/微观环境暴露与短期/长期健康后果之间的因果关系提供新的见解。
