Silva Gabriela M, França-Falcão Maria S, Calzerra Natália Tabosa M, Luz Mickael S, Gadelha Danilo Duarte A, Balarini Camille M, Queiroz Thyago M
Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vitória de Santo Antão, Brazil.
Center of Biotechnology, Federal University of Paraiba, João Pessoa, Brazil.
Front Physiol. 2020 Sep 3;11:1067. doi: 10.3389/fphys.2020.01067. eCollection 2020.
Atherosclerosis is the leading cause of vascular disease worldwide and contributes significantly to deaths from cardiovascular complications. There is a remarkably close relationship between atherosclerotic plaque formation and the activation of renin-angiotensin system (RAS). However, depending on which RAS pathway is activated, pro- or anti-atherogenic outcomes may be observed. This brief review focuses on the role of three of the most important pieces of RAS axis, angiotensin II (Ang-II), angiotensin converting enzyme type 2 (ACE2), and angiotensin 1-7 (Ang-1-7) and their involvement in atherosclerosis. We focused on the effects of these molecules on vascular function and inflammation, which are important determinants of atherogenesis. Furthermore, we highlighted potential pharmacological approaches to treat this disorder.
动脉粥样硬化是全球血管疾病的主要原因，对心血管并发症导致的死亡有重大影响。动脉粥样硬化斑块形成与肾素-血管紧张素系统（RAS）的激活之间存在非常密切的关系。然而，根据激活的RAS途径不同，可能会观察到促动脉粥样硬化或抗动脉粥样硬化的结果。本简要综述重点关注RAS轴中三个最重要的部分，即血管紧张素II（Ang-II）、2型血管紧张素转换酶（ACE2）和血管紧张素1-7（Ang-1-7）的作用及其在动脉粥样硬化中的参与情况。我们重点关注了这些分子对血管功能和炎症的影响，而血管功能和炎症是动脉粥样硬化形成的重要决定因素。此外，我们强调了治疗这种疾病的潜在药理学方法。
