Wu Fan, Wang Xiaoyu, Li Xianjun, Jiang Haoxiang, Huang Tingting, Liu Congcong, Wang Miaomiao, Zhai Zhonghui, Zhang Xiaoman, Zhang Jingjing, Liu Heng, Yang Jian
Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Radiology, Guangzhou Women and Children's Medical Center, Affiliated Guangzhou Medical University, Guangzhou, China.
Front Neurol. 2020 Sep 8;11:955. doi: 10.3389/fneur.2020.00955. eCollection 2020.
Brain imaging is important in diagnosing children with cerebral palsy (CP) and in identifying its etiology. To provide study navigation in this field, a bibliometric analysis was conducted by analyzing the most highly cited articles. The Web of Science All Databases were used for literature search in this study. All original articles on imaging in children with CP were searched. Two reviewers screened the search results independently and eliminated articles based on exclusion criteria such as participants over 20 years old, topics referring to images outside of the brain, or trauma. According to descending order of yearly citation counts, the top 25% of all included articles were considered as highly cited articles. Information such as yearly citations, research purposes, imaging modalities, CP types, and study designs were recorded and analyzed. A total of 50 highly cited articles ranked by yearly citations (from 23.85 to 3.33, 1991-2018) were included in this study. Considering different research purposes, these studies were classified into three categories: diagnosis studies ( = 25; 1991-2017, median: 2011), mechanism studies ( = 15; 1999-2018; median: 2014), and prognosis and therapeutic effect studies ( = 10; 2008-2017; median: 2014.5). First, for diagnosis studies, 22 studies used single modality and three used multi-modalities; the majority of these studies focused on diagnostic value evaluation ( = 10) and image performance ( = 12) of a single type of CP ( = 15) by using descriptive ( = 14) or cross-sectional approaches ( = 10). Second, for mechanism studies, the ratio between single and multi-modality was 8:7; most of these studies concentrated on a single subtype of spastic CP (hemiplegia = 10, quadriplegia = 2) with a cross-sectional study design ( = 10). Third, regarding the prognosis and therapeutic effect studies, the single vs. multi-modality ratio was 5:5, and these studies were dedicated to the efficiency of constraint-induced movement therapy in children with hemiplegia; paired design trials ( = 6) and randomized controlled trials ( = 2) were used more frequently. Studies using multi-modality and high-level evidence-based design to provide information regarding mechanism, prognosis, and therapeutic efficacy may be the potential future research direction in the field of CP research.
脑成像在脑瘫（CP）患儿的诊断及其病因识别中具有重要意义。为了在该领域提供研究导航，通过分析被引频次最高的文章进行了文献计量分析。本研究使用科学网所有数据库进行文献检索。检索了所有关于CP患儿成像的原创文章。两名评审员独立筛选检索结果，并根据排除标准排除文章，如参与者年龄超过20岁、主题涉及脑外图像或创伤。根据年被引频次的降序排列，所有纳入文章中前25%被视为高被引文章。记录并分析年被引频次、研究目的、成像方式、CP类型和研究设计等信息。本研究共纳入了50篇按年被引频次排名的高被引文章（1991 - 2018年，年被引频次从23.85到3.33）。考虑到不同的研究目的，这些研究分为三类：诊断研究（n = 25；1991 - 2017年，中位数：2011年）、机制研究（n = 15；1999 - 2018年；中位数：2014年）以及预后和治疗效果研究（n = 10；2008 - 2017年；中位数：2014.5年）。首先，对于诊断研究，22项研究使用单一模式，3项使用多模式；这些研究中的大多数通过描述性（n = 14）或横断面方法（n = 10），聚焦于单一类型CP（n = 15）的诊断价值评估（n = 10）和图像性能（n = 12）。其次，对于机制研究，单一模式与多模式的比例为8:7；这些研究中的大多数集中于痉挛性CP的单一亚型（偏瘫n = 10，四肢瘫n = 2），采用横断面研究设计（n = 10）。第三，关于预后和治疗效果研究，单一模式与多模式的比例为5:5，这些研究致力于偏瘫患儿强制性诱导运动疗法的疗效；配对设计试验（n = 6）和随机对照试验（n = 2）使用更为频繁。使用多模式和高级循证设计来提供关于机制、预后和治疗疗效信息的研究可能是CP研究领域未来潜在的研究方向。
