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卡铂治疗转移性膀胱移行细胞癌的II期研究(医学研究委员会泌尿生殖系统癌症工作组晚期膀胱癌亚组报告)

A phase II study of carboplatin in metastatic transitional cell carcinoma of the bladder (a report of the Medical Research Council Working Party on Urological Cancer, Subgroup in Advanced Bladder Cancer).

出版信息

Eur J Cancer Clin Oncol. 1987 Apr;23(4):375-7.

PMID:3301367
Abstract

In view of the activity of Cisplatin in bladder cancer a multicentre study of its less toxic analogue Carboplatin was carried out in 48 patients with metastatic transitional cell carcinoma, of whom 30 had received no previous cytotoxic chemotherapy. No complete remissions and only 3 partial responses were observed, suggesting that Carboplatin has only minimal activity in this disease.

摘要

鉴于顺铂对膀胱癌的活性,对其毒性较小的类似物卡铂进行了一项多中心研究,该研究纳入了48例转移性移行细胞癌患者,其中30例此前未接受过细胞毒性化疗。未观察到完全缓解,仅观察到3例部分缓解,这表明卡铂在该疾病中的活性极小。

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1
A phase II study of carboplatin in metastatic transitional cell carcinoma of the bladder (a report of the Medical Research Council Working Party on Urological Cancer, Subgroup in Advanced Bladder Cancer).卡铂治疗转移性膀胱移行细胞癌的II期研究(医学研究委员会泌尿生殖系统癌症工作组晚期膀胱癌亚组报告)
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引用本文的文献

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2
Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines.一种新型铂类类似物洛铂在顺铂敏感和耐药的人睾丸癌、卵巢癌及胃癌细胞系中的临床前活性。
Cancer Chemother Pharmacol. 1993;33(1):43-7. doi: 10.1007/BF00686021.
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A pharmacologically guided phase I study of carboplatin in combination with methotrexate and vinblastine in advanced urothelial cancer.
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Cancer Chemother Pharmacol. 1995;35(5):391-6. doi: 10.1007/s002800050252.
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Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer.卡铂。对其药效学、药代动力学特性及在癌症治疗中的疗效的初步综述。
Drugs. 1989 Feb;37(2):162-90. doi: 10.2165/00003495-198937020-00005.
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