Gui Fu, You Zhipeng, Fu Shuhua, Wu Hongxi, Zhang Yulan
Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Front Endocrinol (Lausanne). 2020 Sep 4;11:591. doi: 10.3389/fendo.2020.00591. eCollection 2020.
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and receptors, pro-inflammatory cytokines and chemokines, proliferator-activated receptor-γ disruption, growth factors, oxidative stress, and microRNA. These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.
糖尿病视网膜病变（DR）是一种糖尿病并发症，会影响视网膜功能，导致严重的视力丧失及相关视网膜疾病。由多种因素引起的视网膜血管功能障碍，如晚期糖基化终产物及其受体、促炎细胞因子和趋化因子、增殖激活受体γ破坏、生长因子、氧化应激和微小RNA。这些因素会促进视网膜内皮功能障碍，进而导致糖尿病视网膜病变的发生。在本综述中，我们总结了糖尿病视网膜病变病理生理学中的相关因素，以便更好地理解糖尿病视网膜病变发生发展的分子和细胞机制，尤其着重于视网膜内皮功能障碍。
