Fan Dengjian, Wang Mingshu, Cheng Anchun, Jia Renyong, Yang Qiao, Wu Ying, Zhu Dekang, Zhao Xinxin, Chen Shun, Liu Mafeng, Zhang Shaqiu, Ou Xumin, Mao Sai, Gao Qun, Sun Di, Wen Xingjian, Liu Yunya, Yu Yanling, Zhang Ling, Tian Bin, Pan Leichang, Chen Xiaoyue
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Front Microbiol. 2020 Aug 18;11:1910. doi: 10.3389/fmicb.2020.01910. eCollection 2020.
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral replication, VP16, as a tegument, is involved in viral assembly. This review will explain the mechanism of VP16 acting as α-TIF to activate the transcription of viral immediate-early genes, its role in the transition from viral latency to reactivation, and its effects on viral assembly and maturation. In addition, this review also provides new insights for further research on the life cycle of alphaherpesviruses and the role of VP16 in the viral life cycle.
α疱疹病毒UL48基因编码的蛋白质被命名为VP16或α基因反式激活因子（α-TIF）。在病毒复制早期，VP16是一种重要的反式激活因子，可激活病毒立即早期基因的转录，而在病毒复制后期，VP16作为一种被膜蛋白，参与病毒组装。本文将阐述VP16作为α-TIF激活病毒立即早期基因转录的机制、其在病毒潜伏到激活转变过程中的作用以及对病毒组装和成熟的影响。此外，本文还为进一步研究α疱疹病毒的生命周期以及VP16在病毒生命周期中的作用提供了新的见解。
