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基于普鲁卡因的ProcCluster阻碍单纯疱疹病毒1型的第二次包膜化过程。

The Procaine-Based ProcCluster Impedes the Second Envelopment Process of Herpes Simplex Virus Type 1.

作者信息

Jungwirth Johannes, Siegert Lisa, Gauthier Lena, Henke Andreas, Krämer Oliver H, Engert Beatrice, Ehrhardt Christina

机构信息

Section of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knoell-Str. 2, D-07745 Jena, Germany.

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

出版信息

Int J Mol Sci. 2025 Jul 25;26(15):7185. doi: 10.3390/ijms26157185.

DOI:10.3390/ijms26157185
PMID:40806319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346171/
Abstract

Herpes simplex virus type 1 (HSV-1) has a global prevalence of 64%. Established antiviral drugs, such as acyclovir (ACV), have been successfully used over the past decades. However, due to growing viral resistance against approved antivirals and the lack of effective vaccines, new concepts are essential to target HSV-1 infections. Here, we present data on the inhibitory effect of the procaine-based substance ProcCluster (PC) in reducing HSV-1 replication in vitro. Non-toxic PC concentrations significantly decreased HSV-1 replication in infected cells. Immunofluorescence microscopy revealed an accumulation of viral proteins in early and recycling endosomes, resulting in reduced viral release. The combination of PC with ACV resulted in an enhanced antiviral effect. Based on these results, PC alone, as well as in combination with ACV, appears to be a promising substance with antiviral potential against HSV-1 infections.

摘要

单纯疱疹病毒1型（HSV-1）在全球的流行率为64%。在过去几十年中，已成功使用了如阿昔洛韦（ACV）等已有的抗病毒药物。然而，由于病毒对已批准抗病毒药物的耐药性不断增加以及缺乏有效的疫苗，针对HSV-1感染的新概念至关重要。在此，我们展示了基于普鲁卡因的物质ProcCluster（PC）在体外减少HSV-1复制的抑制作用的数据。无毒的PC浓度显著降低了感染细胞中HSV-1的复制。免疫荧光显微镜检查显示病毒蛋白在早期和循环内体中积累，导致病毒释放减少。PC与ACV联合使用产生了增强的抗病毒效果。基于这些结果，单独使用PC以及与ACV联合使用似乎都是具有抗HSV-1感染抗病毒潜力的有前景的物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/2a411fc15ad9/ijms-26-07185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/4f719eab083e/ijms-26-07185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/d94e313b6bc9/ijms-26-07185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/16b50a3f2970/ijms-26-07185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/2a411fc15ad9/ijms-26-07185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/4f719eab083e/ijms-26-07185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/d94e313b6bc9/ijms-26-07185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/16b50a3f2970/ijms-26-07185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1052/12346171/2a411fc15ad9/ijms-26-07185-g004.jpg

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The Procaine-Based ProcCluster Impedes the Second Envelopment Process of Herpes Simplex Virus Type 1.

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本文引用的文献

[1]
Combined use of pritelivir with acyclovir or foscarnet suppresses evolution of HSV-1 drug resistance.

Virus Evol. 2024-11-23

[2]
An updated review of HSV-1 infection-associated diseases and treatment, vaccine development, and vector therapy application.

Virulence. 2024-12

[3]
ProcCluster® and procaine hydrochloride inhibit the growth of species and exert antimicrobial properties during coinfection with influenza A viruses and .

Front Cell Infect Microbiol. 2024

[4]
A review of HSV pathogenesis, vaccine development, and advanced applications.

Mol Biomed. 2024-8-29

[5]
ProcCluster and procaine hydrochloride inhibit the replication of influenza A virus .

Front Microbiol. 2024-8-14

[6]
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1.

Antimicrob Agents Chemother. 2024-5-2

[7]
The Local Anaesthetic Procaine Prodrugs ProcCluster and Procaine Hydrochloride Impair SARS-CoV-2 Replication and Egress In Vitro.

Int J Mol Sci. 2023-9-26

[8]
Management of oral herpes simplex virus infections: The problem of resistance. A narrative review.

Oral Dis. 2024-4

[9]
Rab GTPases as Modulators of Vascular Function.

Cells. 2022-9-29

[10]
Knockout of signal peptide peptidase in the eye reduces HSV-1 replication and eye disease in ocularly infected mice.

PLoS Pathog. 2022-10

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