Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Front Immunol. 2020 Aug 18;11:1845. doi: 10.3389/fimmu.2020.01845. eCollection 2020.
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 1990s, the study of MAIT cells has grown substantially, accelerating our fundamental understanding of these cells and their possible roles in immunity. In the context of recent advances, we review here the relationship between MR1, antigen, and TCR usage among MAIT and other MR1-reactive T cells and provide a speculative discussion.
黏膜相关恒定 T（MAIT）细胞是一种非常规 T 细胞亚群，其识别进化上保守的主要组织相容性复合体（MHC）I 类样抗原呈递分子，称为 MHC I 类相关蛋白 1（MR1）。自 20 世纪 90 年代初从默默无闻中崛起以来，MAIT 细胞的研究取得了实质性进展，加速了我们对这些细胞及其在免疫中的可能作用的基本理解。在最近的进展背景下，我们在这里回顾了 MAIT 细胞和其他 MR1 反应性 T 细胞之间的 MR1、抗原和 TCR 使用之间的关系，并进行了推测性讨论。
