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腺苷酸环化酶毒素对单核细胞-巨噬细胞分化的影响。

Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.

机构信息

Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the CAS, Prague, Czechia.

出版信息

Front Immunol. 2020 Sep 11;11:2181. doi: 10.3389/fimmu.2020.02181. eCollection 2020.

DOI:10.3389/fimmu.2020.02181
PMID:33013916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7516048/
Abstract

Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity of adenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.

摘要

循环炎症性单核细胞被吸引到感染的黏膜上，并分化为具有增强杀菌和抗原呈递能力的巨噬细胞或树突状细胞。在这篇简要的观点文章中，我们讨论了一个新出现的观点，即腺苷酸环化酶毒素的 cAMP 信号能力如何操纵单核细胞的分化，并触发肺泡巨噬细胞的去分化，从而促进细菌在人体气道的定植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cd/7516048/f09d078e1b34/fimmu-11-02181-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cd/7516048/cd9cd3189560/fimmu-11-02181-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cd/7516048/f09d078e1b34/fimmu-11-02181-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cd/7516048/cd9cd3189560/fimmu-11-02181-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cd/7516048/f09d078e1b34/fimmu-11-02181-g0002.jpg

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Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.效应蛋白 BteA 的细胞毒性在百日咳博德特氏菌中通过插入一个丙氨酸残基而减弱。
PLoS Pathog. 2020 Aug 10;16(8):e1008512. doi: 10.1371/journal.ppat.1008512. eCollection 2020 Aug.
2
Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells.腺苷酸环化酶毒素抑制单核细胞向巨噬细胞的转化，并将人肺泡巨噬细胞去分化为单核细胞样细胞。
mBio. 2019 Sep 24;10(5):e01743-19. doi: 10.1128/mBio.01743-19.
3
Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.
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Eosinophils as drivers of bacterial immunomodulation and persistence.嗜酸性粒细胞作为细菌免疫调节和持续存在的驱动因素。
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