Afshari Amir R, Mollazadeh Hamid, Sahebkar Amirhossein
Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
J Oncol. 2020 Sep 17;2020:8659802. doi: 10.1155/2020/8659802. eCollection 2020.
One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.
中枢神经系统病理最致命的形式之一是多形性胶质母细胞瘤（GBM），它具有高侵袭性、不受控制的增殖和血管生成特征。其侵袭性导致即使在最大程度的手术干预后仍有高复发率。米诺环素是四环素的半合成类似物，具有潜在的抗炎和抗癌作用，与其抗菌活性不同。在本综述中，我们强调了米诺环素对GBM病理生理学的重要性和细胞毒性机制。考虑到某些酶在自噬、凋亡、肿瘤细胞侵袭和转移能力中的作用，应研究四环素在癌症治疗中的可能用途，尤其是对GBM的治疗。因此，本研究将涵盖迄今为止米诺环素药理学的主要主题，鼓励将其作为癌症和GBM的一种新治疗方法加以考虑。
