• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

多黏菌素B引起的皮肤色素沉着过度。

Polymyxin B-Induced Skin Hyperpigmentation.

作者信息

Wen Xueke, Luo Chunliu, Lyu Weitao

机构信息

The First Clinical Medical College of Jinan University, No. 601 Huangpu Avenue West, Guangzhou City 510630, Guangdong Province, China.

The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou City 510630, Guangdong Province, China.

出版信息

Case Rep Med. 2020 Sep 18;2020:6461329. doi: 10.1155/2020/6461329. eCollection 2020.

DOI:10.1155/2020/6461329
PMID:33014066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7519980/
Abstract

Polymyxin B-induced skin hyperpigmentation is a rare adverse drug reaction (ADR). In this report, we present the case of a patient who underwent an abscess resection with right epididymitis, in which a multidrug-resistant infection (KPI) is formed. The patient was treated with polymyxin B and subsequently developed skin hyperpigmentation and desquamation. The desquamation improved and the pigmentation gradually returned to normal after sixty days after the withdrawal of polymyxin B.

摘要

多粘菌素B引起的皮肤色素沉着是一种罕见的药物不良反应(ADR)。在本报告中,我们介绍了一例患者,该患者因右附睾炎接受脓肿切除术,术中形成了多重耐药感染(KPI)。患者接受了多粘菌素B治疗,随后出现皮肤色素沉着和脱屑。停药60天后,脱屑情况改善,色素沉着逐渐恢复正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b7/7519980/7e19f818b513/CRIM2020-6461329.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b7/7519980/7e19f818b513/CRIM2020-6461329.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b7/7519980/7e19f818b513/CRIM2020-6461329.001.jpg

相似文献

1
Polymyxin B-Induced Skin Hyperpigmentation.多黏菌素B引起的皮肤色素沉着过度。
Case Rep Med. 2020 Sep 18;2020:6461329. doi: 10.1155/2020/6461329. eCollection 2020.
2
Polymyxin B-induced skin hyperpigmentation: a rare case report and literature review.多粘菌素B引起的皮肤色素沉着过度:1例罕见病例报告及文献复习
BMC Pharmacol Toxicol. 2018 Jul 4;19(1):41. doi: 10.1186/s40360-018-0226-1.
3
Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.多黏菌素B诱导的弥漫性皮肤色素沉着。
J Clin Diagn Res. 2017 Feb;11(2):FD01-FD02. doi: 10.7860/JCDR/2017/24278.9213. Epub 2017 Feb 1.
4
Rare occurrence of polymyxin B-induced hyperpigmentation in a child with ventriculitis.儿童脑室炎中多黏菌素 B 诱导的色素沉着罕见发生。
BMJ Case Rep. 2023 Apr 11;16(4):e253959. doi: 10.1136/bcr-2022-253959.
5
Skin hyperpigmentation following intravenous polymyxin B treatment associated with melanocyte activation and inflammatory process.静脉注射多黏菌素B治疗后出现的皮肤色素沉着与黑素细胞激活及炎症过程有关。
J Clin Pharm Ther. 2017 Oct;42(5):573-578. doi: 10.1111/jcpt.12543. Epub 2017 May 11.
6
Successful treatment of ceftazidime-resistant Klebsiella pneumoniae ventriculitis with intravenous meropenem and intraventricular polymyxin B: case report and review.静脉注射美罗培南联合脑室内注射多黏菌素B成功治疗耐头孢他啶肺炎克雷伯菌脑室炎:病例报告及文献复习
Clin Infect Dis. 1999 May;28(5):1134-8. doi: 10.1086/514754.
7
Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae.新型多黏菌素联合抗艾滋病药物齐多夫定对产 NDM 耐药肺炎克雷伯菌具有协同杀菌作用。
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.02176-18. Print 2019 Apr.
8
Polymyxin B clinical outcomes: A prospective study of patients undergoing intravenous treatment.多黏菌素 B 的临床疗效:一项静脉治疗患者的前瞻性研究。
J Clin Pharm Ther. 2019 Jun;44(3):415-419. doi: 10.1111/jcpt.12801. Epub 2019 Jan 21.
9
Extended spectrum beta-lactamase-producing Klebsiella pneumoniae chronic ambulatory peritoneal dialysis peritonitis treated successfully with polymyxin B.产超广谱β-内酰胺酶的肺炎克雷伯菌所致慢性非卧床腹膜透析腹膜炎经多粘菌素B成功治疗
Heart Lung. 2005 Sep-Oct;34(5):360-3. doi: 10.1016/j.hrtlng.2004.11.001.
10
Emergence of polymyxin B resistance in a polymyxin B-susceptible KPC-producing Klebsiella pneumoniae causing bloodstream infection in a neutropenic patient during polymyxin B therapy.在一名中性粒细胞减少患者接受多粘菌素B治疗期间,一株对多粘菌素B敏感且产KPC的肺炎克雷伯菌引起血流感染,并出现了对多粘菌素B的耐药性。
Diagn Microbiol Infect Dis. 2018 Feb;90(2):134-138. doi: 10.1016/j.diagmicrobio.2017.10.006. Epub 2017 Oct 19.

引用本文的文献

1
Drug-Induced Pigmentation: A Review.药物诱导性色素沉着:综述。
Drugs. 2024 Sep;84(9):1071-1091. doi: 10.1007/s40265-024-02062-z. Epub 2024 Aug 1.
2
Clinical efficacy and nephrotoxicity of intravenous colistin sulfate in the treatment of carbapenem-resistant gram-negative bacterial infections: a retrospective cohort study.硫酸多黏菌素静脉注射治疗耐碳青霉烯革兰阴性菌感染的临床疗效及肾毒性:一项回顾性队列研究
Ann Transl Med. 2022 Oct;10(20):1137. doi: 10.21037/atm-22-4959.
3
Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis.

本文引用的文献

1
Drug-Induced Hyperpigmentation: Review and Case Series.药物诱导性色素沉着:综述与病例系列。
J Am Board Fam Med. 2019 Jul-Aug;32(4):628-638. doi: 10.3122/jabfm.2019.04.180212.
2
Skin hyperpigmentation following intravenous polymyxin B treatment associated with melanocyte activation and inflammatory process.静脉注射多黏菌素B治疗后出现的皮肤色素沉着与黑素细胞激活及炎症过程有关。
J Clin Pharm Ther. 2017 Oct;42(5):573-578. doi: 10.1111/jcpt.12543. Epub 2017 May 11.
3
Acquired skin hyperpigmentation following intravenous polymyxin B treatment: a cohort study.
蛋白质组学反应揭示了涉及多粘菌素 B 诱导黑色素生成机制的信号通路。
Microbiol Spectr. 2022 Apr 27;10(2):e0273021. doi: 10.1128/spectrum.02730-21. Epub 2022 Apr 4.
4
Pharmacokinetics and pharmacodynamics of peptide antibiotics.肽类抗生素的药代动力学和药效学。
Adv Drug Deliv Rev. 2022 Apr;183:114171. doi: 10.1016/j.addr.2022.114171. Epub 2022 Feb 18.
5
The Difference Between Polymyxin B and Polymyxin E in Causing Skin Hyerpigmentation.多粘菌素B和多粘菌素E在引起皮肤色素沉着方面的差异。
Front Pharmacol. 2021 Apr 16;12:647564. doi: 10.3389/fphar.2021.647564. eCollection 2021.
静脉注射多粘菌素B治疗后获得性皮肤色素沉着:一项队列研究。
Pigment Cell Melanoma Res. 2016 May;29(3):388-90. doi: 10.1111/pcmr.12468. Epub 2016 Mar 17.
4
Colistin neurotoxicity: revisited.黏菌素神经毒性:再探讨
BMJ Case Rep. 2015 Jul 23;2015:bcr2015210787. doi: 10.1136/bcr-2015-210787.
5
Polymyxin B Induced Generalized Hyperpigmentation in Neonates.多黏菌素B导致新生儿全身性色素沉着
Indian J Pediatr. 2016 Feb;83(2):179-80. doi: 10.1007/s12098-015-1798-z. Epub 2015 Jun 20.
6
Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways.多粘菌素诱导的小鼠肾毒性涉及线粒体、死亡受体和内质网途径。
Antimicrob Agents Chemother. 2014 Jul;58(7):4075-85. doi: 10.1128/AAC.00070-14. Epub 2014 May 5.
7
Drug-induced hperpigemntation: a systematic review.药物诱导的色素沉着:系统评价。
J Dtsch Dermatol Ges. 2013 Jul;11(7):644-51. doi: 10.1111/ddg.12042. Epub 2013 May 8.
8
Polymyxins revisited.多粘菌素再探讨。
Clin Microbiol Rev. 2008 Jul;21(3):449-65. doi: 10.1128/CMR.00006-08.
9
The histamine-cytokine network in allergic inflammation.
J Allergy Clin Immunol. 2003 Oct;112(4 Suppl):S83-8. doi: 10.1016/s0091-6749(03)01881-5.
10
Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes.组胺通过人正常黑素细胞中的H2受体激活蛋白激酶A来诱导黑素生成和形态学变化。
J Invest Dermatol. 2000 Feb;114(2):334-42. doi: 10.1046/j.1523-1747.2000.00874.x.