油对小鼠学习和记忆功能改善的影响。
Effects of Oil on the Improvement of Learning and Memory Function in Mice.
作者信息
Wu Rui, Zhong Shaoqi, Ni Mengmei, Zhu Xuejiao, Chen Yiyi, Chen Xuxi, Zhang Lishi, Chen Jinyao
机构信息
Department of Nutrition, Food Safety and Toxicology, West China School of Public Health and Healthy Food Evaluation Research Center, Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.
West China Hospital Sichuan University, Chengdu, China.
出版信息
Evid Based Complement Alternat Med. 2020 Sep 15;2020:8617143. doi: 10.1155/2020/8617143. eCollection 2020.
BACKGROUND
The fruits of have been highly sought after medically because its seeds have high oil content (>60%), especially the highest known proportion of nervonic acid (>55%). The objective was to explore the effects of different doses of oil (MOC oil) on the learning and memory of mice and to evaluate whether additional DHA algae oil and vitamin E could help MOC oil improve learning and memory and its possible mechanisms.
METHODS
After 30 days of oral administration of the relevant agents to mice, behavioral tests were conducted as well as detection of oxidative stress parameters (superoxide dismutase, malondialdehyde, and glutathione peroxidase) and biochemical indicators (acetylcholine, acetyl cholinesterase, and choline acetyltransferase) in the hippocampus.
RESULTS
Experimental results demonstrated that MOC oil treatment could markedly improve learning and memory of mouse models in behavioral experiments and increase the activity of GSH-PX in hippocampus and reduce the content of MDA, especially the dose of 46.27 mg/kg. The addition of DHA and VE could better assist MOC oil to improve the learning and memory, and its mechanism may be related to the inhibition of oxidative stress and restrain the activity of AChE and also increase the content of ACh.
CONCLUSION
Our results demonstrated that MOC oil treatment could improve learning and memory impairments. Therefore, we suggest that MOC oil is a potentially important resource for the development of nervonic acid products.
背景
[某种植物]果实因其种子含油量高（>60%）而备受医学关注，尤其是神经酸含量极高（>55%），为已知最高比例。目的是探究不同剂量的[某种植物]油（MOC油）对小鼠学习记忆的影响，并评估添加DHA藻油和维生素E是否有助于MOC油改善学习记忆及其可能机制。
方法
给小鼠口服相关制剂30天后，进行行为测试，并检测海马体中的氧化应激参数（超氧化物歧化酶、丙二醛和谷胱甘肽过氧化物酶）以及生化指标（乙酰胆碱、乙酰胆碱酯酶和胆碱乙酰转移酶）。
结果
实验结果表明，MOC油处理可在行为实验中显著改善小鼠模型的学习记忆能力，增加海马体中GSH - PX的活性并降低MDA含量，尤其是46.27 mg/kg剂量组。添加DHA和VE可更好地协助MOC油改善学习记忆，其机制可能与抑制氧化应激、抑制AChE活性以及增加ACh含量有关。
结论
我们的结果表明，MOC油处理可改善学习记忆障碍。因此，我们认为MOC油是开发神经酸产品的潜在重要资源。
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