Li Xiao, Li Ting, Hong Xiao Yue, Liu Jian Jun, Yang Xi Fei, Liu Gong Ping
Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Front Cell Dev Biol. 2021 May 14;9:680386. doi: 10.3389/fcell.2021.680386. eCollection 2021.
Aging, characterized by a time-dependent functional decline of physiological integrity, is the major independent risk factor for many neurodegeneration diseases. Therefore, it's necessary to look for natural food supplements to extend the healthy lifespan of aging people. We here treated normal aging mice with acer truncatum seed oil, and found that the seed oil significantly improved the learning and memory ability. Proteomics revealed that the seed oil administration changed many proteins expression involving in biological processes, including complement and coagulation cascades, inflammatory response pathway and innate immune response. BDNF/TrkB signaling pathway was also activated by acer truncatum seed oil treatment. And the seed oil administration increased the expression of postsynaptic related proteins including PSD95, GluA1, and NMDAR1, and decreased the mRNA level of inflammatory factors containing IL-1β, TNF-α, and IL-6. These findings suggest that acer truncatum seed oil holds a promise as a therapeutic food supplement for delaying aging with multiple mechanisms.
衰老以生理完整性随时间推移的功能衰退为特征，是许多神经退行性疾病的主要独立危险因素。因此，有必要寻找天然食品补充剂来延长老年人的健康寿命。我们在此用元宝枫籽油处理正常衰老小鼠，发现该籽油显著提高了学习和记忆能力。蛋白质组学显示，施用该籽油改变了许多参与生物过程的蛋白质表达，包括补体和凝血级联反应、炎症反应途径和固有免疫反应。元宝枫籽油处理还激活了BDNF/TrkB信号通路。施用该籽油增加了包括PSD95、GluA1和NMDAR1在内的突触后相关蛋白的表达，并降低了含有IL-1β、TNF-α和IL-6的炎症因子的mRNA水平。这些发现表明，元宝枫籽油有望作为一种具有多种作用机制的延缓衰老的治疗性食品补充剂。
