Khaleefah Muntadher M, Narayanan Siddharth, Dallal Hiba A Al, Jones Christopher M, Friedland Robert P, Palade Adriana E, Remmel Kerri S, Shah Jignesh J
Department of Neurology, University of Louisville Hospital, University of Louisville, Louisville, KY 40202, USA.
Department of Surgery, University of Louisville Hospital, University of Louisville, Louisville, KY 40202, USA.
Oncol Lett. 2020 Dec;20(6):285. doi: 10.3892/ol.2020.12147. Epub 2020 Sep 23.
An isolated third nerve palsy presenting as the primary manifestation of a lymphoma is rare, with only few cases having been described. The present study reports an unusual case of a healthy 67-year old male diagnosed with isolated right oculomotor nerve palsy (ONP), who was found to have an underlying B cell lymphoma. The patient's medical records were accessed upon consent. A thorough physical examination, including stroke and infections work-ups were performed. A chest computerized tomography (CT), brain magnetic resonance imaging and positron emission tomography (PET) scans and a mediastinal tissue biopsy, were performed as part of systematic diagnostic evaluations. The current report suggests that a PET fluorodeoxyglucose study or a CT scan of the chest, abdomen and pelvis (with contrast) may help in the early diagnosis of a cancer responsible for ONP, particularly if brain vessel imaging does not show a posterior cerebral artery aneurysm as a cause for the defect.
孤立性动眼神经麻痹作为淋巴瘤的主要表现较为罕见，仅有少数病例被报道。本研究报告了一例不寻常的病例，一名67岁健康男性被诊断为孤立性右眼动眼神经麻痹（ONP），结果发现其患有潜在的B细胞淋巴瘤。经患者同意后查阅了其病历。进行了全面的体格检查，包括中风和感染方面的检查。作为系统诊断评估的一部分，进行了胸部计算机断层扫描（CT）、脑部磁共振成像和正电子发射断层扫描（PET）以及纵隔组织活检。本报告表明，PET氟脱氧葡萄糖检查或胸部、腹部和骨盆的CT扫描（增强）可能有助于早期诊断导致ONP的癌症，特别是当脑血管成像未显示大脑后动脉动脉瘤是导致该缺陷的原因时。
