Takkamoto Daiji, Kawahara Takashi, Tokita Takashi, Kasuga Jun, Yumura Yasushi, Uemura Hiroji
Department of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama, Japan.
Department of Urology, Toshiba Rinkan Hospital, Sagamihara, Japan.
Oncotarget. 2020 Sep 22;11(38):3526-3530. doi: 10.18632/oncotarget.27719.
Sarcopenia was initially recognized as a marker representing the nutritional condition or aging. Recently, sarcopenia has been associated with a poor prognosis and postoperative complications. We examined the importance of sarcopenia as a predictive marker of the prognosis in penile cancer.
A total of 25 patients diagnosed with penile cancer who underwent penile resection from 2000 to 2010 were analyzed in this study. The psoas muscle index (PMI) was calculated based on psoas area using preoperative axial computed tomography images at the right L3 level divided by the square of the body height.
Nineteen (76.0%) patients underwent partial penectomy, and 6 (24.0%) underwent total penectomy. The median (mean ± standard deviation) age was 69.3 (69.0 ± 10.1) years old. Regarding the site of penile cancer, 17 (76.0%) cases were in the glans, 6 (24.0%) were in the foreskin, and 2 (8.0%) were in the shaft. Lymph node metastasis were seen in 6 cases (24.0%), and distant metastasis was seen in 1 case (4.0%). The lower PMI group (< 320.0) showed a significantly poorer progression-free survival than the higher PMI group (≥ 320.0) ( = 0.030), although no significant difference in the overall survival was noted ( = 0.076).
Sarcopenia might be a useful prognostic factor in penile cancer patients.
肌肉减少症最初被认为是代表营养状况或衰老的一个指标。最近，肌肉减少症与预后不良和术后并发症相关。我们研究了肌肉减少症作为阴茎癌预后预测指标的重要性。
本研究分析了2000年至2010年期间共25例诊断为阴茎癌并接受阴茎切除术的患者。使用术前L3右侧水平的轴向计算机断层扫描图像，根据腰大肌面积计算腰大肌指数（PMI），再将其除以身高的平方。
19例（76.0%）患者接受了部分阴茎切除术，6例（24.0%）接受了全阴茎切除术。中位（平均±标准差）年龄为69.3（69.0±10.1）岁。关于阴茎癌的部位，17例（76.0%）位于龟头，6例（24.0%）位于包皮，2例（8.0%）位于阴茎体。6例（24.0%）出现淋巴结转移，1例（4.0%）出现远处转移。较低PMI组（<320.0）的无进展生存期明显低于较高PMI组（≥320.0）（P = 0.030），尽管总体生存期无显著差异（P = 0.076）。
肌肉减少症可能是阴茎癌患者有用的预后因素。
