糖尿病患者红细胞山梨醇含量：与代谢控制的关系。

Erythrocyte sorbitol content in diabetic patients: relation to metabolic control.

作者信息

Vertommen J, Rillaerts E, Gysels M, De Leeuw I

出版信息

Diabete Metab. 1987 Jun;13(3):182-6.

Abstract

Since intracellular sorbitol is considered a factor perhaps involved in the pathogenesis of some diabetic complications, erythrocyte sorbitol content was measured in diabetics (IDDM and NIDDM) and in a control group and its relation with metabolic control was investigated. The erythrocyte sorbitol content was significantly increased in diabetic population (p less than 0.001) as compared to the controls. In newly diagnosed IDDMs the erythrocyte sorbitol content changed in parallel with the blood sugar level indicating that the accumulation can be reversed in erythrocytes. In a cross-sectional study a significant positive correlation existed in IDDMs between the concentration of red cell sorbitol and the plasma glucose concentration (r = 0.45; p less than 0.001). Also the HbA1 values correlated (r = 0.44; p less than 0.001) with the erythrocyte sorbitol content. In NIDDMs no correlation with metabolic control could be demonstrated.

摘要

由于细胞内山梨醇被认为可能是某些糖尿病并发症发病机制中的一个因素，因此对糖尿病患者（胰岛素依赖型糖尿病和非胰岛素依赖型糖尿病）和对照组的红细胞山梨醇含量进行了测量，并研究了其与代谢控制的关系。与对照组相比，糖尿病患者的红细胞山梨醇含量显著增加（p<0.001）。在新诊断的胰岛素依赖型糖尿病患者中，红细胞山梨醇含量与血糖水平平行变化，这表明红细胞中的积累可以逆转。在一项横断面研究中，胰岛素依赖型糖尿病患者的红细胞山梨醇浓度与血浆葡萄糖浓度之间存在显著正相关（r = 0.45；p<0.001）。糖化血红蛋白值也与红细胞山梨醇含量相关（r = 0.44；p<0.001）。在非胰岛素依赖型糖尿病患者中，未发现与代谢控制相关。