Papadimitriou Konstantinos I, Vidal Rosas Ernesto E, Zhang Edward, Cooper Robert J, Hebden Jeremy C, Arridge Simon R, Powell Samuel
Department of Computer Science, University College London, London, WC1E 6BT, UK.
These authors contributed equally to this work.
Biomed Opt Express. 2020 Jun 2;11(7):3477-3490. doi: 10.1364/BOE.393586. eCollection 2020 Jul 1.
Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments.
近红外光谱已被证明是一种用于无创、实时监测组织氧合和血流动力学的重要方法。对这些参数进行量化需要测量光在组织中的飞行时间，通常使用皮秒脉冲激光器来实现，但其成本、复杂性和尺寸都较高。在这项工作中，我们提出了一种替代方法，该方法采用扩频激励，以开发一种使用垂直腔面发射激光器的小型、低成本双波长系统。由于我们之前的单波长演示平台中使用的商用模块无法提供光谱学的最佳波长和驱动参数，因此我们详细介绍了定制仪器的设计，并展示了其在呼吸暂停和认知任务实验中解析人体血流动力学变化的性能。
