光学相干断层扫描血管造影术用于评估产前暴露于尼古丁引起的小鼠胎儿脑血管系统变化。
Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine.
作者信息
Raghunathan Raksha, Liu Chih-Hao, Ambekar Yogeshwari S, Singh Manmohan, Miranda Rajesh C, Larin Kirill V
机构信息
Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd., Houston, TX 77204, USA.
Department of Neuroscience and Experimental Therapeutics, TAMHSC College of Medicine, 8441 Riverside Parkway, Bryan, TX 77807, USA.
出版信息
Biomed Opt Express. 2020 Jun 8;11(7):3618-3632. doi: 10.1364/BOE.394905. eCollection 2020 Jul 1.
Abstract
Maternal smoking causes several defects ranging from intrauterine growth restriction to sudden infant death syndrome and spontaneous abortion. While several studies have documented the effects of prenatal nicotine exposure in development and behavior, acute vasculature changes in the fetal brain due to prenatal nicotine exposure have not been evaluated yet. This study uses correlation mapping optical coherence angiography to evaluate changes in fetal brain vasculature flow caused by maternal exposure to nicotine during the second trimester-equivalent of gestation in a mouse model. The effects of two different doses of nicotine were evaluated. Results showed a decrease in the vasculature for both doses of nicotine, which was not seen in the case of the sham group.
摘要
母亲吸烟会导致多种缺陷，从宫内生长受限到婴儿猝死综合征和自然流产。虽然多项研究记录了产前尼古丁暴露对发育和行为的影响，但产前尼古丁暴露导致的胎儿脑血管急性变化尚未得到评估。本研究使用相关映射光学相干血管造影术，在小鼠模型中评估相当于妊娠中期的孕期母体接触尼古丁所引起的胎儿脑血管血流变化。评估了两种不同剂量尼古丁的影响。结果显示，两种剂量的尼古丁均导致血管减少，而假手术组未出现这种情况。
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