Harju E, Nordback I
J Int Med Res. 1987 May-Jun;15(3):167-9. doi: 10.1177/030006058701500307.
The effect of an anti-cholinergic drug (atropine) on insulin secretion was studied in a double-blind manner by the glucagon C-peptide secretion test in five healthy subjects and controlled with saline only (placebo) in four subjects. Blood C-peptide increased only by 157% in the group given atropine and by 252% in the group given placebo. The blood glucose concentration increased by 25% and 32%, respectively. Thus, it is concluded that the cholinergic system, probably through the vagus nerve, has an insulin secretion stimulating effect. The results also suggest that denervation of the vagus nerve, e.g. in gastric surgery, may partly explain post-prandial hyperglycaemia particularly found in dumping.
通过胰高血糖素C肽分泌试验，以双盲方式对5名健康受试者研究了抗胆碱能药物（阿托品）对胰岛素分泌的影响，并用生理盐水（安慰剂）对4名受试者进行对照。给予阿托品的组中血C肽仅增加157%，给予安慰剂的组中增加252%。血糖浓度分别升高25%和32%。因此，得出结论：胆碱能系统可能通过迷走神经对胰岛素分泌有刺激作用。结果还表明，迷走神经去神经支配，如在胃手术中，可能部分解释了尤其是在倾倒综合征中出现的餐后高血糖。
