Korakiti Anna-Maria, Moutafi Myrto, Zografos Eleni, Dimopoulos Meletios-Athanasios, Zagouri Flora
Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Front Oncol. 2020 Sep 11;10:1773. doi: 10.3389/fonc.2020.01773. eCollection 2020.
Breast cancer is the most common malignancy diagnosed during pregnancy. Strong data on the genomic profile of pregnancy-associated breast cancer are lacking. This systematic review aims to integrate and analyze all existing data from the literature regarding the genomic background and the gene mutational patterns of pregnancy-associated breast cancer. Using various genomic analysis methods, multiple differentially expressed genes and numerous non-silent mutations have been detected. More particularly, our review demonstrates the aberrant expression of several oncogenes (e.g., ), tumor suppressor genes (e.g., ), apoptosis regulators (e.g., ), transcription regulators (e.g., ), genes involved in DNA repair mechanisms (e.g., Sig20, ), in cell proliferation (e.g., ), in the immune response (e.g., ), and in other significant biological processes (e.g., protein modification, internal cell motility). Further research on the genomic profile of pregnancy-associated breast cancer is urgently required in order to identify potential biomarkers facilitating early-stage diagnosis and individualized therapy.
乳腺癌是孕期诊断出的最常见恶性肿瘤。目前缺乏关于妊娠相关乳腺癌基因组特征的有力数据。本系统综述旨在整合和分析文献中所有关于妊娠相关乳腺癌基因组背景和基因突变模式的现有数据。使用各种基因组分析方法，已检测到多个差异表达基因和大量非同义突变。更具体地说，我们的综述表明，几种癌基因（如 ）、肿瘤抑制基因（如 ）、凋亡调节因子（如 ）、转录调节因子（如 ）、参与DNA修复机制的基因（如Sig20 ）、细胞增殖相关基因（如 ）、免疫反应相关基因（如 ）以及其他重要生物学过程（如蛋白质修饰、细胞内运动）存在异常表达。迫切需要对妊娠相关乳腺癌的基因组特征进行进一步研究，以确定有助于早期诊断和个体化治疗的潜在生物标志物。
