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[1-谷氨酰胺和二丙基乙酸作为辅助精神药物治疗精神科住院患者。对抗精神病药物用量的影响]

[1-glutamine and dipropylacetic acid as subsidiary psychotropic agents in the treatment of psychiatric in-patients. Effect on the neuroleptic consumption].

作者信息

Cocchi R, Mastruzzo A, Ciccone A, Osvaldi M L

出版信息

Encephale. 1977;3(2):121-32.

PMID:330149
Abstract

In a division of the neuropsychiatric hospital of Racconigi, with acute and chronic inpatients, the use of 1-glutamine and N-dipropylacetic acid as subsidiary psychodrugs, after one year follow-up, showed to have reduced the whole administration of neuroleptics, without diminishing the therapeutic efficacity. This administration, during the four sampler months (December, March, June and September), face with the sames of the preceding year, has been lesser than 29,04% (lesser than 38,21%, if we take into consideration the last two months). Such result has been confirmed by a corresponding diminution of orphenadrine, the drug used to counteract the neuroleptic syndrome, which during the last two months considered in this research, respectively subsided of 28,57% and 36,36%.

摘要

在拉科尼吉神经精神病医院的一个科室,针对急性和慢性住院患者,使用L-谷氨酰胺和N-二丙基乙酸作为辅助精神药物,经过一年的随访,结果显示减少了抗精神病药物的总体使用量,且并未降低治疗效果。在四个采样月(12月、3月、6月和9月)期间,与上一年同期相比,这种使用量减少了29.04%(如果考虑最后两个月,则减少了38.21%)。用于对抗抗精神病综合征的奥芬那君的相应减少证实了这一结果,在本研究中考虑的最后两个月里,其用量分别减少了28.57%和36.36%。

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