Glass A R, Swerdloff R S
Endocrinology. 1977 Sep;101(3):702-7. doi: 10.1210/endo-101-3-702.
Female rats fed a low-valine diet from the time of weaning have been shown to have delayed puberty compared to growth-matched controls. To explore the mechanism of this delay, serum LH and FSH were measured in rats fed the low-valine diet and in growth-matched control rats at several ages prior to puberty. Hormonal determinations at each time point were made both in the basal state and after LHRH administration or castration. After age 27 days, the mean basal serum FSH was lower in the low-valine group than in the control group. The mean serum levels of LH and FSH after oophorectomy were significantly lower in the low-valine group than in the control group, although the mean serum levels of LH and FSH after LHRH administration to intact animals were similar in both groups. The combination of impaired response to castration with unimpaired pituitary response to LHRH suggests that the low-valine group had a hypothalamic defect which accounts for their delayed sexual maturation when compared to growth-matched animals.
从断奶时起就喂食低缬氨酸饮食的雌性大鼠，与生长匹配的对照组相比，已被证明青春期延迟。为了探究这种延迟的机制，在青春期前的几个年龄段，对喂食低缬氨酸饮食的大鼠和生长匹配的对照大鼠测量了血清促黄体生成素（LH）和促卵泡生成素（FSH）。在每个时间点，都在基础状态以及注射促性腺激素释放激素（LHRH）或去势后进行激素测定。27日龄后，低缬氨酸组的平均基础血清FSH低于对照组。去卵巢后，低缬氨酸组的LH和FSH平均血清水平显著低于对照组，尽管完整动物注射LHRH后两组的LH和FSH平均血清水平相似。对去势反应受损与垂体对LHRH反应未受损相结合，表明低缬氨酸组存在下丘脑缺陷，这解释了与生长匹配的动物相比它们性成熟延迟的原因。
