Houde A, Weber J M
Gene. 1987;54(1):51-6. doi: 10.1016/0378-1119(87)90346-5.
A fragment of DNA containing the protease gene and 3' and 5' flanking regions of human adenovirus type 4 (Ad4) has been cloned and sequenced. The gene is located between 59 and 62 map units and codes for a protein of 201 amino acids with a calculated Mr of 22,758. The Ad4 protease has a 72% amino acid homology with the Ad2 protease, the divergence being concentrated in the middle of the molecule. Comparison with other mammalian and bacterial proteases failed to reveal any significant homology and in particular a putative active site. The adenoviral proteases may therefore represent a novel class of enzymes.
一段包含人4型腺病毒（Ad4）蛋白酶基因以及3'和5'侧翼区域的DNA片段已被克隆并测序。该基因位于59至62个图距单位之间，编码一种由201个氨基酸组成的蛋白质，计算分子量为22,758。Ad4蛋白酶与Ad2蛋白酶具有72%的氨基酸同源性，差异集中在分子中部。与其他哺乳动物和细菌蛋白酶进行比较未发现任何显著同源性，尤其是未发现假定的活性位点。因此，腺病毒蛋白酶可能代表一类新型酶。
