Djuichou Nguemnang Stephanie Flore, Tsafack Eric Gonzal, Mbiantcha Marius, Ateufack Gilbert, Yousseu Nana William, Atsamo Albert Donatien, Adjouzem Carine Flore, Matah Marthe Mba Vanessa, Ben Besong Egbe
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon.
Laboratory of Animal Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Adv Pharmacol Pharm Sci. 2020 Sep 21;2020:8886894. doi: 10.1155/2020/8886894. eCollection 2020.
Diabetic neuropathy, which affects 7 to 9% of the world's population and that is usually accompanied by anxiety and depression, is chronic pain that results from impaired function of the central or peripheral nervous system. This study aimed at evaluating the antihypernociceptive, antiallodynic, anxiolytic, and antidepressant effects of extracts. Diabetic neuropathy was induced by intraperitoneal injection of streptozotocin (200 mg/kg) in mice. The aqueous and ethanol extracts (250 and 500 mg/kg) were administered orally. Hyperalgesia (thermal and chemical), allodynia (mechanical and thermal), anxiety (high plus labyrinth, light-dark box, and social interaction), and depression (open field test, suspension test tail, and forced swimming test) were evaluated, and then the levels of some cytokines and growth factors were determined. The aqueous and ethanol extracts of demonstrated significant antihypernociceptive (inhibition of hyperalgesia and allodynia), anxiolytic, and antidepressant activities in mice made diabetic by STZ. The extracts also significantly inhibited ( < 0.001) the levels of TNF-, IL-1, and IL-6 in the blood as well as the levels of TNF-, IL-1, IL-6, IGF, and NGF in the sciatic nerve. This study shows that the extracts of have antihypernociceptive and neuroprotective effects which could be linked to the inhibition of proinflammatory cytokines and growth factors in the blood and the sciatic nerve.
糖尿病神经病变影响着全球7%至9%的人口，通常伴有焦虑和抑郁，是一种由中枢或周围神经系统功能受损导致的慢性疼痛。本研究旨在评估[提取物名称]提取物的抗伤害性感受、抗痛觉过敏、抗焦虑和抗抑郁作用。通过给小鼠腹腔注射链脲佐菌素（200mg/kg）诱导糖尿病神经病变。口服给予水提取物和乙醇提取物（250mg/kg和500mg/kg）。评估痛觉过敏（热刺激和化学刺激）、痛觉异常（机械刺激和热刺激）、焦虑（高架十字迷宫、明暗箱和社交互动）以及抑郁（旷场试验、悬尾试验和强迫游泳试验），然后测定一些细胞因子和生长因子的水平。[提取物名称]的水提取物和乙醇提取物在链脲佐菌素诱导的糖尿病小鼠中表现出显著的抗伤害性感受（抑制痛觉过敏和痛觉异常）、抗焦虑和抗抑郁活性。提取物还显著抑制（P<0.001）血液中TNF-α、IL-1和IL-6的水平以及坐骨神经中TNF-α、IL-1、IL-6、IGF和NGF的水平。本研究表明，[提取物名称]提取物具有抗伤害性感受和神经保护作用，这可能与抑制血液和坐骨神经中的促炎细胞因子和生长因子有关。
