福斯克水提取物和乙醇提取物对大鼠影响的行为学评价

Behavioral Evaluation of the Effects of Aqueous and Ethanol Extracts of Forssk on Rats.

作者信息

Mohammed Hamdoon A

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, 51452, Saudi Arabia.

出版信息

Cent Nerv Syst Agents Med Chem. 2020;20(2):122-127. doi: 10.2174/1871524920666200319142536.

DOI:10.2174/1871524920666200319142536

PMID:32189599

Abstract

BACKGROUND

Suaeda vermiculata is one of the widely distributed halophytes in central Saudi Arabia. The plant is used as a remedy for liver diseases, jaundice, and inflammation. S. vermiculata is also used as camels' food by local shepherds.

PURPOSE

The study aims to evaluate the behavioral antidepressant and anxiolytic effects of S. vermiculata aqueous and ethanol extracts.

METHODS

Aqueous and ethanol extracts of S. vermiculata were prepared by the maceration technique. Standard forced swim test cylinder and light/dark chamber device were used to evaluate the antidepressant and anxiolytic activities of the extracts (200 mg/kg) in rats model, respectively.

RESULTS

The aqueous and ethanol extracts of S. vermiculata showed remarkable antidepressant activity with significant increase in the swimming time and reduced immobility in the rats compared to imipramine treated animals (P<0.05). Ethanol extract increased the swimming time by 20% and decreased the immobility time by more than 60% compared to the control group of animals. In contrast, the extracts induced the anxiety behavior in experimental rats compared to vehicle- treated animals. The extracts significantly (P<0.001) reduced the time spent by rats in the light chamber by more than 50% and increased the time spent in dark chamber as compared with the control group and the group receiving diazepam.

CONCLUSION

The medicinally important plant S. vermiculata induced anxiety behavior with antidepressant activity in rats. These effects from our point of view are similar to the effects of some common beverages containing caffeine such as coffee and tea.

摘要

背景

蠕形碱蓬是沙特阿拉伯中部广泛分布的盐生植物之一。该植物被用作治疗肝脏疾病、黄疸和炎症的药物。蠕形碱蓬还被当地牧民用作骆驼的食物。

目的

本研究旨在评估蠕形碱蓬水提取物和乙醇提取物的行为抗抑郁和抗焦虑作用。

方法

采用浸渍技术制备蠕形碱蓬的水提取物和乙醇提取物。分别使用标准强迫游泳试验缸和明暗箱装置评估提取物（200mg/kg）在大鼠模型中的抗抑郁和抗焦虑活性。

结果

与丙咪嗪治疗的动物相比，蠕形碱蓬的水提取物和乙醇提取物显示出显著的抗抑郁活性，大鼠的游泳时间显著增加，不动时间减少（P<0.05）。与动物对照组相比，乙醇提取物使游泳时间增加了20%，不动时间减少了60%以上。相比之下，与赋形剂处理的动物相比，提取物在实验大鼠中诱导了焦虑行为。与对照组和接受地西泮的组相比，提取物使大鼠在明箱中的停留时间显著减少（P<0.001），超过50%，并增加了在暗箱中的停留时间。