Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II. Naples.
Arch Ital Urol Androl. 2020 Oct 1;92(3). doi: 10.4081/aiua.2020.3.173.
We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid in patients with lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH).
We performed a retrospective matched paired comparison. The clinical records of LUTS/BPH patients who underwent medical therapy with tamsulosin 0.4 mg/day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid between January 2019 to September 2019 were reviewed (Group 1). These patients were compared in a 1:1 fashion with LUTS/BPH patients who underwent therapy with tamsulosin 0.4 mg/day alone (Group 2). Total, storage, voiding and Quality of Life (QoL) international prostate symptom (IPSS) score, as well as overactive bladder (OAB)-v8 score and treatment- related adverse events recorded at 40 days follow-up in both groups were compared.
At 40 days follow-up mean total, storage, voiding and QoL IPSS sub-scores as well as OAB-v8 score significantly improved in both groups. Intergroup comparison showed statistically significant lower mean total IPSS score (11.6 vs 12.4, p = 0.04) mean storage IPSS sub-score (6.5 vs 7.5, p = 0.01), and mean OAB v8 score (16.7 vs 18.8, p = 0.03) in patients in the Group 1.
The combination of tamsulosin 0.4 mg/die plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid LGlutamine bid provides statistically significant advantages in terms of storage LUTS improvements in patients with LUTS/BPH compared to tamsulosin 0.4 mg/day alone. These findings are preliminary and further prospective studies on a greater number of patients are needed to confirm it.
我们旨在比较坦索罗辛 0.4mg 每日一次单药治疗与坦索罗辛 0.4mg 每日一次联合补充和替代医学治疗（包括维生素（C 和 D）、草药（南瓜、辣椒、龙葵）和氨基酸 L-谷氨酰胺）治疗下尿路症状相关良性前列腺增生（LUTS/BPH）患者的疗效。
我们进行了回顾性配对比较。回顾性分析 2019 年 1 月至 2019 年 9 月接受坦索罗辛 0.4mg/天联合补充和替代医学治疗（包括维生素（C 和 D）、草药（南瓜、辣椒、龙葵）和氨基酸 L-谷氨酰胺）的 LUTS/BPH 患者的临床资料（1 组）。这些患者按 1:1 的比例与接受坦索罗辛 0.4mg/天单药治疗的 LUTS/BPH 患者（2 组）进行比较。比较两组患者在 40 天随访时的总、储存、排尿和生活质量（QoL）国际前列腺症状（IPSS）评分，以及膀胱过度活动症（OAB）-v8 评分和治疗相关不良反应。
两组患者在 40 天随访时总、储存、排尿和 QoL IPSS 评分以及 OAB-v8 评分均显著改善。组间比较显示，第 1 组患者的总 IPSS 评分（11.6 比 12.4，p=0.04）、储存 IPSS 亚评分（6.5 比 7.5，p=0.01）和 OAB-v8 评分（16.7 比 18.8，p=0.03）均显著降低。
与坦索罗辛 0.4mg/天单药治疗相比，坦索罗辛 0.4mg/天联合补充和替代医学治疗（包括维生素（C 和 D）、草药（南瓜、辣椒、龙葵）和氨基酸 L-谷氨酰胺）可显著改善 LUTS/BPH 患者的储存期 LUTS。这些发现是初步的，需要进一步进行更大规模患者的前瞻性研究来证实。
