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痛风患者良性前列腺增生(BPH)风险增加:一项基于全国健康筛查队列的纵向随访研究

Increased Risk of Benign Prostate Hyperplasia (BPH) in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.

作者信息

Bang Woo Jin, Choi Hyo Geun, Kang Ho Suk, Kwon Mi Jung, Kim Ji Hee, Kim Joo-Hee, Kim So Young

机构信息

Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.

Suseoseoulent Clinic, Seoul 06349, Republic of Korea.

出版信息

Diagnostics (Basel). 2023 Dec 26;14(1):55. doi: 10.3390/diagnostics14010055.


DOI:10.3390/diagnostics14010055
PMID:38201364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10871099/
Abstract

A previous study reported a high risk of benign prostatic hyperplasia (BPH) in patients with gout. This study intended to evaluate the risk of BPH in gout patients. A total of 514,866 Korean National Health Insurance Service-Health Screening Cohorts were retrieved from 2002 to 2019. Among these individuals, 14,961 gout patients and 58,764 control participants were matched based on demographic factors. The incidence of BPH during the follow-up periods was collected for both the gout and control groups. The risk of BPH was analyzed using stratified Cox proportional hazard models, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Secondary analyses were conducted based on demographic factors and comorbidities. The incidence of BPH was 23.40% in gout patients and 20.70% in control participants. In the adjusted model, the HR of BPH was 1.13-fold higher in gout patients than in the control group (95% CI = 1.09-1.18). Compared with the ≥60-year-old group, the <60-year-old group demonstrated a higher HR for BPH in gout patients (1.19 [1.13-1.24] vs. 1.07 [1.01-1.13]). The risk of BPH in gout patients was consistent according to various comorbidities. Patients with gout demonstrated a greater risk of BPH than participants without gout. The young adult population had a higher risk of BPH related to gout.

摘要

先前的一项研究报告称痛风患者患良性前列腺增生(BPH)的风险较高。本研究旨在评估痛风患者患BPH的风险。从2002年至2019年共检索了514,866名韩国国民健康保险服务健康筛查队列参与者。在这些个体中,根据人口统计学因素匹配了14,961名痛风患者和58,764名对照参与者。收集了痛风组和对照组在随访期间BPH的发病率。使用分层Cox比例风险模型分析BPH的风险,并计算风险比(HRs)和95%置信区间(CIs)。基于人口统计学因素和合并症进行了二次分析。痛风患者中BPH的发病率为23.40%,对照参与者中为20.70%。在调整模型中,痛风患者BPH的HR比对照组高1.13倍(95%CI = 1.09 - 1.18)。与≥60岁组相比,<60岁组痛风患者BPH的HR更高(1.19 [1.13 - 1.24]对1.07 [1.01 - 1.13])。根据各种合并症,痛风患者患BPH的风险是一致的。痛风患者患BPH的风险高于非痛风参与者。年轻成年人群患与痛风相关的BPH的风险更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6940/10871099/5fbc3aa80e66/diagnostics-14-00055-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6940/10871099/0ecc7c2adbb6/diagnostics-14-00055-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6940/10871099/5fbc3aa80e66/diagnostics-14-00055-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6940/10871099/0ecc7c2adbb6/diagnostics-14-00055-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6940/10871099/5fbc3aa80e66/diagnostics-14-00055-g002.jpg

相似文献

[1]
Increased Risk of Benign Prostate Hyperplasia (BPH) in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.

Diagnostics (Basel). 2023-12-26

[2]
Association of alpha-1-adrenergic antagonist use with the risk of gout development in benign prostatic hyperplasia patients: a population-based cohort study.

Fam Pract. 2022-5-28

[3]
Risk of incident benign prostatic hyperplasia in patients with gout: a retrospective cohort study.

Prostate Cancer Prostatic Dis. 2018-6-1

[4]
Hyperlipidemia is associated with an increased risk of clinical benign prostatic hyperplasia.

Prostate. 2018-2

[5]
Impact of Benign Prostatic Hyperplasia and/or Prostatitis on the Risk of Prostate Cancer in Korean Patients.

World J Mens Health. 2021-4

[6]
Hyperthyroidism is not a significant risk of benign prostatic hyperplasia: A nationwide population-based study.

Medicine (Baltimore). 2018-9

[7]
The Occurrence of Nephrolithiasis in Gout Patients: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.

Life (Basel). 2022-4-28

[8]
Benign prostatic hyperplasia is a significant risk factor for bladder cancer in diabetic patients: a population-based cohort study using the National Health Insurance in Taiwan.

BMC Cancer. 2013-1-4

[9]
The Risk of BPPV, Meniere's Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.

J Clin Med. 2022-12-26

[10]
Increased risk of atrial fibrillation in patients with benign prostatic hyperplasia: A population-based cohort study.

Clin Cardiol. 2018-10

本文引用的文献

[1]
Aging-Related Mitochondrial Dysfunction Is Associated With Fibrosis in Benign Prostatic Hyperplasia.

J Gerontol A Biol Sci Med Sci. 2024-6-1

[2]
A Novel Low-Cost Uroflowmetry for Patient Telemonitoring.

Int J Environ Res Public Health. 2023-2-13

[3]
Robotic assisted simple prostatectomy versus other treatment modalities for large benign prostatic hyperplasia: a systematic review and meta-analysis of over 6500 cases.

Prostate Cancer Prostatic Dis. 2023-9

[4]
Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study.

J Transl Med. 2022-10-29

[5]
Higher Levels of Serum Uric Acid Have a Significant Association with Lower Incidence of Lower Urinary Tract Symptoms in Healthy Korean Men.

Metabolites. 2022-7-14

[6]
The Association between Serum Testosterone and Hyperuricemia in Males.

J Clin Med. 2022-5-12

[7]
Medical Treatment of Benign Prostatic Hyperplasia.

Urol Clin North Am. 2022-5

[8]
Identification of Inflammation-Related Biomarker Pro-ADM for Male Patients With Gout by Comprehensive Analysis.

Front Immunol. 2021

[9]
Association of alpha-1-adrenergic antagonist use with the risk of gout development in benign prostatic hyperplasia patients: a population-based cohort study.

Fam Pract. 2022-5-28

[10]
Gout.

Lancet. 2021-5-15

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