Bang Woo Jin, Choi Hyo Geun, Kang Ho Suk, Kwon Mi Jung, Kim Ji Hee, Kim Joo-Hee, Kim So Young
Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Suseoseoulent Clinic, Seoul 06349, Republic of Korea.
Diagnostics (Basel). 2023 Dec 26;14(1):55. doi: 10.3390/diagnostics14010055.
A previous study reported a high risk of benign prostatic hyperplasia (BPH) in patients with gout. This study intended to evaluate the risk of BPH in gout patients. A total of 514,866 Korean National Health Insurance Service-Health Screening Cohorts were retrieved from 2002 to 2019. Among these individuals, 14,961 gout patients and 58,764 control participants were matched based on demographic factors. The incidence of BPH during the follow-up periods was collected for both the gout and control groups. The risk of BPH was analyzed using stratified Cox proportional hazard models, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Secondary analyses were conducted based on demographic factors and comorbidities. The incidence of BPH was 23.40% in gout patients and 20.70% in control participants. In the adjusted model, the HR of BPH was 1.13-fold higher in gout patients than in the control group (95% CI = 1.09-1.18). Compared with the ≥60-year-old group, the <60-year-old group demonstrated a higher HR for BPH in gout patients (1.19 [1.13-1.24] vs. 1.07 [1.01-1.13]). The risk of BPH in gout patients was consistent according to various comorbidities. Patients with gout demonstrated a greater risk of BPH than participants without gout. The young adult population had a higher risk of BPH related to gout.
先前的一项研究报告称痛风患者患良性前列腺增生(BPH)的风险较高。本研究旨在评估痛风患者患BPH的风险。从2002年至2019年共检索了514,866名韩国国民健康保险服务健康筛查队列参与者。在这些个体中,根据人口统计学因素匹配了14,961名痛风患者和58,764名对照参与者。收集了痛风组和对照组在随访期间BPH的发病率。使用分层Cox比例风险模型分析BPH的风险,并计算风险比(HRs)和95%置信区间(CIs)。基于人口统计学因素和合并症进行了二次分析。痛风患者中BPH的发病率为23.40%,对照参与者中为20.70%。在调整模型中,痛风患者BPH的HR比对照组高1.13倍(95%CI = 1.09 - 1.18)。与≥60岁组相比,<60岁组痛风患者BPH的HR更高(1.19 [1.13 - 1.24]对1.07 [1.01 - 1.13])。根据各种合并症,痛风患者患BPH的风险是一致的。痛风患者患BPH的风险高于非痛风参与者。年轻成年人群患与痛风相关的BPH的风险更高。
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