Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia.
Immunol Cell Biol. 2020 Nov;98(10):802-804. doi: 10.1111/imcb.12403. Epub 2020 Oct 5.
Ng et al. have identified NKG7 as a regulator of inflammation in response to diverse immunological challenges. While NKG7 was required for the degranulation of cytotoxic cells, additional defects including reduced expansion and trafficking of CD8 T cells, and altered antigen presentation, were noted in NKG7-deficient mice. The precise mechanism by which NKG7 mediates its effects has not been resolved but may involve regulation of endosomal vesicle trafficking.
吴等人已经鉴定出 NKG7 是一种针对多种免疫挑战的炎症反应调节剂。虽然 NKG7 是细胞毒性细胞脱颗粒所必需的，但在 NKG7 缺陷小鼠中还观察到其他缺陷，包括 CD8 T 细胞的扩增和迁移减少，以及抗原呈递改变。NKG7 介导其作用的确切机制尚未解决，但可能涉及内体囊泡运输的调节。
