[不同亚型缺血性卒中患者血浆中的氨基硫醇]

[Aminothiols in blood plasma at different subtypes of ischemic stroke].

作者信息

Maksimova M Yu, Ivanov A V, Nikiforova K A, Virus E D, Suanova E T, Ochtova F R, Piradov M A, Kubatiev A A

机构信息

Research Center of Neurology, Moscow, Russia.

Institute of General Pathology and Pathophysiology, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8. Vyp. 2):17-23. doi: 10.17116/jnevro202012008217.

DOI:10.17116/jnevro202012008217

PMID:33016672

Abstract

OBJECTIVE

To evaluate the hemostasis of plasma aminothiols in different subtypes of ischemic stroke (IS).

MATERIAL AND METHODS

The study included 177 patients, aged 62 (55-68) years, admitted in the first 8-24 hours since IS onset. The pathogenetic subtype of IS was clarified according to the results of clinical and instrumental examination by the Trial of ORG 10172 in Acute Stroke Treatment criteria. Determination of the total plasma aminothiols levels, their reduced forms and redox status was performed using the ultra-efficient Acquity H-Class UPLC liquid chromatograph (Waters, CSHA).

RESULTS

Large-artery atherosclerosis was diagnosed in 24.3% patients, cardioembolic stroke in 20.3%, lacunar stroke in 55.4%. Significant differences in total levels of cysteine (Cys), glutathione (Gsh) and homocysteine (Hcy) were identified in patients with different IS subtypes. Patients with large-artery atherosclerosis and lacunar stroke showed the highest level of Hcy, patients with cardioembolic stroke had the lowest levels of Cys and Gsh.

CONCLUSION

Total levels of plasma aminothiols are associated with different subtypes of IS.

摘要

目的

评估血浆氨基硫醇在不同亚型缺血性卒中（IS）中的止血作用。

材料与方法

该研究纳入了177例年龄为62（55 - 68）岁的患者，这些患者在缺血性卒中发作后的最初8 - 24小时内入院。根据急性卒中治疗中ORG 10172试验标准的临床和仪器检查结果明确缺血性卒中的发病机制亚型。使用超高效Acquity H-Class UPLC液相色谱仪（沃特世公司，CSHA）测定血浆氨基硫醇的总水平、其还原形式和氧化还原状态。

结果

24.3%的患者被诊断为大动脉粥样硬化，20.3%为心源性栓塞性卒中，55.4%为腔隙性卒中。在不同缺血性卒中亚型的患者中，半胱氨酸（Cys）、谷胱甘肽（Gsh）和同型半胱氨酸（Hcy）的总水平存在显著差异。大动脉粥样硬化和腔隙性卒中患者的同型半胱氨酸水平最高，心源性栓塞性卒中患者的半胱氨酸和谷胱甘肽水平最低。