Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy.
Neurol Sci. 2009 Aug;30(4):361-4. doi: 10.1007/s10072-009-0090-2. Epub 2009 May 30.
Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B12 and plasma levels of rGSH were significantly lower in the patients than in the control group. Acute LAAS was associated with increased Hcy-decreased tGSH and decreased FA/tGSH. Pathways involved in cellular stress and in tissue repair are activated during acute LAAS.
血液中总同型半胱氨酸（tHcy）、半胱氨酸（Cys）、总谷胱甘肽（tGSH）和还原型谷胱甘肽（rGSH）、叶酸（FA）和维生素 B12（B12）的水平在缺血性脑卒中发生时会发生变化，这是伴随组织损伤而发生的。这些变化之间的关系尚未得到充分研究。我们评估了急性大动脉粥样硬化性血栓性脑卒中（LAAS）后 48 小时内这些分子的变化，并寻找它们之间是否存在匹配的变化。该研究涉及 50 名急性 LAAS 患者和 49 名健康对照者。与对照组相比，患者的血浆 tHcy 和 Cys 水平显著升高，血清 FA 和 B12 水平以及血浆 rGSH 水平显著降低。急性 LAAS 与 Hcy 增加 tGSH 减少和 FA/tGSH 减少有关。急性 LAAS 期间，细胞应激和组织修复相关的途径被激活。
