[Neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress of experimental hemorrhagic stroke].
作者信息
Klyueva L A, Koplik E V, Shvetsov E V, Vasyanina K A
机构信息
Sechenov First Moscow State Medical University, Moscow, Russia.
Anokhin Institute of Normal Physiology the Russian Academy Sciences, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8. Vyp. 2):45-48. doi: 10.17116/jnevro202012008245.
OBJECTIVE
To study neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress in experimental hemorrhagic stroke.
MATERIAL AND METHODS
Evaluation of neurological deficit on the Menzies scale and a histological study of structural features of tracheal lymphoid tissue were performed on days 1, 3 and 7 of experimental hemorrhagic stroke in 98 Wistar male rats with different resistance to emotional stress. Stroke simulation was preceded by animal testing to determine individual stress resistance.
RESULTS AND CONCLUSION
Neurological disorders are more pronounced in non-stress-resistant animals during all periods of observation. Lymphoid nodules of the tracheal wall of rats react with destruction of lymphoid cells and depletion of small lymphocytes observed in stress-resistant rats already on the 1 day of a stroke. On the 3 day, the neurological deficit and changes in the cellular composition of the lymphoid formations of the trachea are most pronounced in both groups of rats. By the 7 day, a positive trend towards the restoration of the structure of tracheal lymphoid tissue and normal neurological status is detected only in rats resistant to emotional stress.
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