Klyueva L A, Koplik E V, Shvetsov E V, Vasyanina K A
Sechenov First Moscow State Medical University, Moscow, Russia.
Anokhin Institute of Normal Physiology the Russian Academy Sciences, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8. Vyp. 2):45-48. doi: 10.17116/jnevro202012008245.
To study neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress in experimental hemorrhagic stroke.
Evaluation of neurological deficit on the Menzies scale and a histological study of structural features of tracheal lymphoid tissue were performed on days 1, 3 and 7 of experimental hemorrhagic stroke in 98 Wistar male rats with different resistance to emotional stress. Stroke simulation was preceded by animal testing to determine individual stress resistance.
Neurological disorders are more pronounced in non-stress-resistant animals during all periods of observation. Lymphoid nodules of the tracheal wall of rats react with destruction of lymphoid cells and depletion of small lymphocytes observed in stress-resistant rats already on the 1 day of a stroke. On the 3 day, the neurological deficit and changes in the cellular composition of the lymphoid formations of the trachea are most pronounced in both groups of rats. By the 7 day, a positive trend towards the restoration of the structure of tracheal lymphoid tissue and normal neurological status is detected only in rats resistant to emotional stress.
研究实验性出血性卒中中对情绪应激具有不同抵抗力的大鼠气管淋巴组织的神经状态和结构变化。
对98只对情绪应激具有不同抵抗力的雄性Wistar大鼠，在实验性出血性卒中的第1、3和7天，采用门齐斯量表评估神经功能缺损，并对气管淋巴组织的结构特征进行组织学研究。在模拟卒中之前，先对动物进行测试以确定个体应激抵抗力。
在所有观察期内，非应激抵抗动物的神经功能障碍更为明显。大鼠气管壁的淋巴小结会发生反应，在卒中第1天，应激抵抗大鼠中就已观察到淋巴样细胞的破坏和小淋巴细胞的耗竭。在第3天，两组大鼠的神经功能缺损以及气管淋巴组织细胞组成的变化最为明显。到第7天，仅在对情绪应激有抵抗力的大鼠中检测到气管淋巴组织结构恢复和神经状态正常的积极趋势。
