Klyueva L V, Koplik E V, Vasyanina K A, Pertsov S S
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia.
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Bull Exp Biol Med. 2019 Apr;166(6):714-718. doi: 10.1007/s10517-019-04424-0. Epub 2019 Apr 24.
Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the development of motor disturbances in the forelimb use asymmetry test and corner rotation paradigm. These animals preferred to use the left forelimb (ipsilateral to the side of hemorrhage) to lean on the cylinder wall. The frequency of using the right forelimb or both forelimbs was reduced under these conditions. The number of left-sided rotations increased, while the percentage of right-sided rotations decreased. The observed changes were accompanied by immune dysfunction. It was manifested in the depletion of lymphoid aggregates of the tracheal wall in lymphocytes and plasma cells. The severity of abnormal neurological symptoms and disturbances in immune homeostasis during the immediate stage of hemorrhagic stroke was greater in behaviorally passive rats than in active specimens.
在具有不同行为参数的大鼠中，研究了出血性中风即刻期（第1天）神经功能缺损的特定特征以及气管淋巴结构细胞组成的变化。在大脑左侧尾状核进行出血建模后，在前肢使用不对称测试和转角旋转范式中出现了运动障碍。这些动物更喜欢用左前肢（与出血侧同侧）靠在圆柱体壁上。在这些情况下，使用右前肢或双前肢的频率降低。左侧旋转次数增加，而右侧旋转的百分比下降。观察到的变化伴随着免疫功能障碍。其表现为气管壁淋巴细胞和浆细胞中的淋巴聚集物减少。行为被动的大鼠在出血性中风即刻期异常神经症状的严重程度和免疫稳态紊乱比活跃的大鼠更大。
