Klyueva L A
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(8. Vyp. 2):63-70. doi: 10.17116/jnevro20171178263-70.
To reveal regularities of changes in cellular composition of lymphoid nodules in the tracheal wall in male Wistar rats resistant and not resistant to emotional stress in a model of hemorrhagic stroke.
Lymphoid formations of the tracheal wall (an area near the bifurcation of the organ) were investigated in 98 male Wistar rats using histological methods.
Significant changes in the cellular composition of lymphoid nodules were found. The pattern of changes depends on the stress resistance of rats and the period of the experiment. The active cell destruction in lymphoid nodules was noted both in stress resistant and stress susceptible animals. The changes in the structure of lymphoid nodules found in the experimental hemorrhagic stroke suggest a decrease in the local immune resistance, which is most pronounced in rats not resistant to stress, that may contribute to the development of severe inflammatory complications of stroke such as pneumonia.
在出血性中风模型中，揭示雄性Wistar大鼠对情绪应激有抗性和无抗性时气管壁淋巴小结细胞组成的变化规律。
采用组织学方法，对98只雄性Wistar大鼠气管壁（器官分叉附近区域）的淋巴组织进行了研究。
发现淋巴小结的细胞组成有显著变化。变化模式取决于大鼠的抗应激能力和实验时期。在抗应激和易应激动物中均观察到淋巴小结中有活跃的细胞破坏现象。实验性出血性中风中发现的淋巴小结结构变化表明局部免疫抵抗力下降，这在对抗应激无抗性的大鼠中最为明显，这可能会导致中风的严重炎症并发症如肺炎的发生。
