Yeung S, Pang G, Cripps A W, Clancy R L, Wlodarczyk J H
Int J Immunopharmacol. 1987;9(3):283-8. doi: 10.1016/0192-0561(87)90052-x.
An oral polybacterial vaccine containing 1.5 X 10(9) killed Haemophilus influenzae per tablet stimulated salivary IgA anti H. influenzae antibody compared to placebo control groups according to statistical analysis using parameter estimates for the logistic model of best fit. Significant antibody secretion could only be demonstrated when three-monthly courses were taken, and when the H. influenzae were combined in a polybacterial mix. This latter form of H. influenzae is functionally defined as adjuvenated. Increasing the immunising dose 60 fold in the absence of the non H. influenzae bacterial species did not stimulate a detectable increase in salivary antibody.
根据对最佳拟合逻辑模型使用参数估计进行的统计分析，与安慰剂对照组相比，每片含有1.5×10⁹ 灭活流感嗜血杆菌的口服多菌疫苗刺激了唾液中抗流感嗜血杆菌IgA抗体的产生。只有在每三个月服用一个疗程，且流感嗜血杆菌与多种细菌混合时，才能证明有显著的抗体分泌。后一种形式的流感嗜血杆菌在功能上被定义为经过佐剂处理。在没有非流感嗜血杆菌菌种的情况下，将免疫剂量增加60倍并没有刺激唾液抗体产生可检测到的增加。
