Clancy R, Cripps A, Murree-Allen K, Yeung S, Engel M
Lancet. 1985;2(8469-70):1395-7. doi: 10.1016/s0140-6736(85)92559-0.
Fifty patients with chronic obstructive lung disease were randomly allocated to three groups, to assess whether an oral vaccine containing non-typable Haemophilus influenzae protected against acute bronchitis. The double-blind prospective study over a three-month winter period included two placebo groups and one test group. Oral immunisation with H influenzae induced a tenfold reduction in the incidence of infection (p less than 0.001). During the subsequent winter, without further immunisation, protection by the vaccine was no longer statistically significant. There was no clear correlation between clinical protection and either carriage of H influenzae or the level of antibody to H influenzae antigen in saliva.
50例慢性阻塞性肺疾病患者被随机分为三组，以评估一种含不可分型流感嗜血杆菌的口服疫苗是否能预防急性支气管炎。这项在冬季为期三个月的双盲前瞻性研究包括两个安慰剂组和一个试验组。用流感嗜血杆菌进行口服免疫使感染发生率降低了10倍（p<0.001）。在随后的冬季，未进行进一步免疫的情况下，疫苗的保护作用在统计学上不再显著。临床保护与流感嗜血杆菌的携带情况或唾液中流感嗜血杆菌抗原抗体水平之间没有明显的相关性。
