Pasquali R, Cesari M P, Melchionda N, Stefanini C, Raitano A, Labo G
Int J Obes. 1987;11(2):163-8.
A double-blind cross-over randomized study was performed in 10 selected adult overweight and obese (body mass index greater than 27) women who had been adapted to low-energy intake for a long period of time and who had shown difficulty in losing weight with conventional hypocaloric treatment. Combined with diet therapy (1000-1400 kcal/day), l(-)ephedrine hydrochloride (50 mg three times a day per os) or placebo were administered daily before each meal, after a period of stabilization with diet only for 1 month. Each pharmacological treatment lasted for 2 months. Weight loss was significantly (P less than 0.05) greater during the ephedrine period (2.41 +/- 0.61 kg) than during the placebo period (0.64 +/- 0.50 kg). None of the patients presented clinically important side-effects. These preliminary results seem to suggest a possible role for a thermogenic compound such as ephedrine in promoting weight loss in low-energy-adapted obese women.
对10名经过挑选的成年超重及肥胖（体重指数大于27）女性进行了一项双盲交叉随机研究。这些女性长期适应低能量摄入，且采用传统低热量疗法减肥困难。在仅通过饮食稳定1个月后，结合饮食疗法（1000 - 1400千卡/天），于每餐饭前每日口服给予盐酸l(-)麻黄碱（50毫克，每日三次）或安慰剂。每种药物治疗持续2个月。麻黄碱治疗期间体重减轻（2.41±0.61千克）显著（P小于0.05）大于安慰剂治疗期间（0.64±0.50千克）。没有患者出现具有临床意义的副作用。这些初步结果似乎表明，像麻黄碱这样的产热化合物在促进适应低能量的肥胖女性减肥方面可能发挥作用。
