• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of cellular glutathione content on the induction of DNA double strand breaks by 25 MeV electrons.

作者信息

Frankenberg D, Kistler M, Eckardt-Schupp F

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Aug;52(2):185-90. doi: 10.1080/09553008714551641.

DOI:10.1080/09553008714551641
PMID:3301713
Abstract

The effect of endogenous glutathione (GSH) on the induction of DNA double strand breaks (dsb) by 25 MeV electrons was investigated using stationary haploid yeast cells defective in gamma-glutamyl-cysteine-synthetase (gsh 1) containing less than 5 per cent of the normal GSH content. In gsh 1 cells the induction of dsb is increased by a factor of 1.5 under oxic and 1.8 under anoxic irradiation conditions: whereas the oxygen enhancement ratio was only slightly decreased (1.9) compared to wild-type cells (2.4).

摘要

相似文献

1
Effect of cellular glutathione content on the induction of DNA double strand breaks by 25 MeV electrons.
Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Aug;52(2):185-90. doi: 10.1080/09553008714551641.
2
The influence of oxygen on the survival and yield of DNA double-strand breaks in irradiated yeast cells.氧气对辐照酵母细胞中DNA双链断裂的存活及产量的影响。
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Sep;36(3):261-70. doi: 10.1080/09553007914551031.
3
Evidence for DNA double-strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions.在有氧或无氧条件下，用稀疏或密集电离辐射照射酵母细胞时，DNA双链断裂作为关键损伤的证据。
Radiat Res. 1981 Dec;88(3):524-32.
4
Exponential or shouldered survival curves result from repair of DNA double-strand breaks depending on postirradiation conditions.指数型或有坪的存活曲线是由DNA双链断裂的修复产生的，这取决于照射后的条件。
Radiat Res. 1988 Apr;114(1):54-63.
5
Mechanisms of oxygen radiosensitization in irradiated yeast. I. DNA double-strand breakage.
Int J Radiat Biol. 1993 Nov;64(5):511-21. doi: 10.1080/09553009314551721.
6
A comparative study of rejoining of DNA double-strand breaks in yeast irradiated with 3.5 MeV alpha-particles or with 30 MeV electrons.
Int J Radiat Biol. 1990 Jun;57(6):1151-68. doi: 10.1080/09553009014551261.
7
Fast kinetics of the oxygen effect for DNA double-strand breakage and cell killing in irradiated yeast.
Int J Radiat Biol. 1990 Mar;57(3):485-501. doi: 10.1080/09553009014552631.
8
Repair of DNA single-strand breaks in X-irradiated yeast. II. Kinetics of repair as measured by the DNA-unwinding method.X射线照射酵母中DNA单链断裂的修复。II. 用DNA解旋法测定的修复动力学。
Mutat Res. 1985 Jul;146(1):63-70. doi: 10.1016/0167-8817(85)90056-2.
9
Heavy ion-induced DNA double-strand breaks in yeast.
Int J Radiat Biol. 1992 Sep;62(3):279-87. doi: 10.1080/09553009214552121.
10
Repair of DNA double-strand breaks as a determinant of RBE of alpha particles.DNA双链断裂修复作为α粒子相对生物学效应的一个决定因素。
Br J Cancer Suppl. 1984;6:169-73.

引用本文的文献

1
In vitro hypoxic cytotoxicity and hypoxic radiosensitization. Efficacy of the novel 2-nitroimidazole N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine.体外缺氧细胞毒性和缺氧放射增敏作用。新型 2-硝基咪唑 N,N,N-三[2-(2-硝基-1H-咪唑-1-基)乙基]胺的疗效。
Strahlenther Onkol. 2013 Mar;189(3):246-54. doi: 10.1007/s00066-012-0273-2. Epub 2013 Jan 31.