Frankenberg-Schwager M, Frankenberg D, Blöcher D, Adamczyk C
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Sep;36(3):261-70. doi: 10.1080/09553007914551031.
Survival and induction of DNA double-strand breaks were studied in cells of Saccharomyces cerevisiae irradiated under oxic or anoxic conditions with 30 MeV electrons. A linear relationship between DNA double-strand breakage and dose was found in both cases. The o.e.r.-value for colony forming ability was found to be 1.9 +/- 0.2, whereas the o.e.r.-value for DNA double-strand breakage was 3.0 +/- 0.1. These results are not inconsistent with the idea that DNA double-strand breaks are involved in killing of yeast cells. The frequency of induction of DNA double-strand breaks was found to be 0.74 x 10(-11) double-strand breaks per g/mol per Gy when cells were irradiated under oxygen and 0.24 x 10(-11) double-strand breaks per g/mol per Gy under nitrogen.
研究了在有氧或无氧条件下，用30兆电子伏特电子辐照的酿酒酵母细胞的存活情况以及DNA双链断裂的诱导情况。在这两种情况下均发现DNA双链断裂与剂量之间呈线性关系。发现集落形成能力的氧增强比（o.e.r.）值为1.9±0.2，而DNA双链断裂的o.e.r.值为3.0±0.1。这些结果与DNA双链断裂参与酵母细胞杀伤的观点并不矛盾。当细胞在氧气中辐照时，发现DNA双链断裂的诱导频率为每戈瑞每克/摩尔0.74×10⁻¹¹个双链断裂，在氮气中为每戈瑞每克/摩尔0.24×10⁻¹¹个双链断裂。
