Saladrigas Mar, Puig Jordi, Bonjoch Josep, Bradshaw Ben
Laboratori de Quı́mica Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain.
Org Lett. 2020 Oct 16;22(20):8111-8115. doi: 10.1021/acs.orglett.0c03081. Epub 2020 Oct 5.
The intermolecular reductive radical coupling of aldehydes with nonactivated alkenes, employing metal hydride atom transfer (MHAT) catalysis with a combination of Fe and Fe salts, is described. This constitutes the first use of aldehydes as viable acceptor groups in MHAT reactions. The insights gained in this study led to the reexamination of the previously reported intramolecular version of the reaction, and the addition of Fe salts allowed the development of a more efficient second-generation approach.
描述了醛与非活化烯烃的分子间还原自由基偶联反应，该反应采用铁和铁盐组合的金属氢化物原子转移（MHAT）催化。这是醛首次在MHAT反应中作为可行的受体基团使用。本研究中获得的见解促使对先前报道的分子内反应版本进行重新审视，并且添加铁盐使得开发出更有效的第二代方法成为可能。
