链霉素的硝基愈创木酚醚衍生物的生物活性

Biological activity of nitroguaiacol ether derivatives of streptomycin.

作者信息

Abad J P, León G, Amils R

出版信息

J Antibiot (Tokyo). 1987 May;40(5):685-91. doi: 10.7164/antibiotics.40.685.

DOI:10.7164/antibiotics.40.685

Abstract

The correlation between the "in vivo" and "in vitro" inhibitory properties of six nitroguaiacol ether derivatives of streptomycin is studied. The differential activity of the derivatives is more closely related to differences in efficiency in the transport of the drugs than to their capacity to inhibit poly(U) directed polyphenylalanine synthesis. The results obtained are discussed in relation to the characteristics of the different derivatives.

摘要

研究了链霉素的六种硝基愈创木酚醚衍生物的“体内”和“体外”抑制特性之间的相关性。这些衍生物的差异活性与其药物转运效率的差异更为密切相关，而非与其抑制多聚（U）指导的聚苯丙氨酸合成的能力相关。结合不同衍生物的特性对所得结果进行了讨论。