Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, PR China; Laboratory of Marine Environmental Science, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 819-0395, Japan.
Laboratory of Marine Environmental Science, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 819-0395, Japan.
Aquat Toxicol. 2020 Nov;228:105643. doi: 10.1016/j.aquatox.2020.105643. Epub 2020 Oct 2.
To better assess the risk of microplastics (MPs) as a vector for contaminants, it is essential to understand the relative importance of MPs compared to other pathways for chemical transfer as well as the consequences of co-exposure. In this study, we exposed Japanese medaka (Oryzias latipes) to anthracene (ANT, 0.1 mg/L) in the presence or absence of pristine polyethylene MPs (PE-MPs, 10 beads/L), to quantify the vector effect of PE-MPs on ANT accumulation. Under the ANT-MPs co-exposure conditions, PE-MPs rapidly accumulated in the gastrointestinal tract of the medaka during a 14-day uptake phase, with an average bioconcentration factor of 171.4 L/kg. The PE-MPs could absorb and accumulate approximately 70 % of the ANT from the water sample. The PE-MPs changed the pharmacokinetic profile of ANT in medaka by decreasing both the uptake and depuration rate constants. The one compartment with first-order elimination model estimated that the amounts of ANT in the water phase and absorbed by PE-MPs (i.e., a vector effect) contributed about 67 % and 33 % of the ANT accumulation in medaka, respectively. At the end of the uptake (exposure) phase, however, the presence of PE-MPs did not significantly alter the final ANT concentrations in the fish body or alter the behavioral impacts of ANT. Thus, PE-MPs ingestion may act as a vector to concentrate and transfer ANT to medaka, but the presence of these particles may have limited adverse effects on fish under co-exposure systems of the type used in this study.
为了更好地评估微塑料（MPs）作为污染物载体的风险，了解 MPs 相对于其他化学物质转移途径的相对重要性以及共暴露的后果至关重要。在这项研究中，我们将日本青鳉暴露于蒽（ANT，0.1mg/L）中，同时存在或不存在原始聚乙烯 MPs（PE-MPs，10 个珠/L），以量化 PE-MPs 对 ANT 积累的载体效应。在 ANT-MPs 共暴露条件下，PE-MPs 在 14 天的吸收期内迅速在青鳉的胃肠道中积累，平均生物浓缩因子为 171.4L/kg。PE-MPs 可以从水样中吸收和积累约 70%的 ANT。PE-MPs 通过降低吸收和清除率常数来改变 ANT 在青鳉中的药代动力学特征。一个具有一阶消除模型的单室模型估计，水相和 PE-MPs 吸收的 ANT 量（即载体效应）分别约占青鳉中 ANT 积累的 67%和 33%。然而，在吸收（暴露）阶段结束时，PE-MPs 的存在并没有显著改变鱼体中的最终 ANT 浓度，也没有改变 ANT 的行为影响。因此，PE-MPs 的摄入可能作为一种载体来浓缩和转移 ANT 到青鳉体内，但在本研究中使用的共暴露系统中，这些颗粒的存在可能对鱼类的不良影响有限。
