噬菌体M13前衣壳的前导（信号）肽对纯化的大肠杆菌前导肽酶的抑制作用。
Inhibition of purified Escherichia coli leader peptidase by the leader (signal) peptide of bacteriophage M13 procoat.
作者信息
Wickner W, Moore K, Dibb N, Geissert D, Rice M
出版信息
J Bacteriol. 1987 Aug;169(8):3821-2. doi: 10.1128/jb.169.8.3821-3822.1987.
Abstract
The leader peptide of bacteriophage M13 procoat inhibited the cleavage of M13 procoat or pre-maltose-binding protein by purified Escherichia coli leader peptidase. This finding confirms inferences that the leader is the primary site of enzyme recognition and suggests a rationale for the rapid hydrolysis of leader peptides in vivo.
摘要
噬菌体M13前衣壳的前导肽抑制了纯化的大肠杆菌前导肽酶对M13前衣壳或前麦芽糖结合蛋白的切割。这一发现证实了前导序列是酶识别的主要位点的推断，并为体内前导肽的快速水解提供了理论依据。
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