Hosseini Saeed, Avci Recep, Paskaranandavadivel Nira, Palmada Nadun, Suresh Vinod, Cheng Leo K
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2384-2387. doi: 10.1109/EMBC44109.2020.9175607.
Gastric motility has a critical role in disintegration and mixing of the ingested food inside the stomach. Several studies have been conducted to quantify and analyze the effect of the contractions of gastric musculature on the stomach contents. Despite the anatomical variation in stomach shape and motility patterns, previous numerical studies employed generalized geometries of the stomach as the computational domain for simulations. To model realistic gastric muscular contractions, the variation in stomach geometries need to be accounted for in numerical simulations. In the current study, a novel method was developed to utilize the recent advances in magnetic resonance imaging (MRI) technology and computational power expansion to build anatomically and physiologically realistic subject specific models of human gastric motility. In this method, MRI scans of the stomach were used to construct two and three dimensional geometry models of gastric motility. MRI was performed on 4 healthy participants. Using the developed method, dynamic numerical geometry models of gastric motility for each participant were constructed and related geometrical calculations were presented. Different combinations of solid and liquid test meals were consumed prior to the scans. The volume of the stomach ranged between 0.36 - 1.10 L in the fed state. The stomach models had an average length of 184 to 226 mm and a maximum diameter of 65 to 102 mm. Contraction propagation speed calculated from the models and MRI data were in good agreement, measuring around 2 mm/s.Clinical relevance- Clinicians can benefit from the proposed method for diagnostic purposes as the method is semi-automatic and can provide dynamic three-dimensional visualization of gastric motility of patients.
胃动力在胃内对摄入食物的分解和混合过程中起着关键作用。已经开展了多项研究来量化和分析胃肌肉组织收缩对胃内容物的影响。尽管胃的形状和动力模式存在解剖学差异，但先前的数值研究采用胃的通用几何形状作为模拟的计算域。为了模拟现实的胃肌肉收缩，在数值模拟中需要考虑胃几何形状的变化。在当前研究中，开发了一种新方法，利用磁共振成像（MRI）技术的最新进展和计算能力的扩展，构建符合解剖学和生理学实际的人体胃动力个体化模型。在该方法中，胃的MRI扫描用于构建胃动力的二维和三维几何模型。对4名健康参与者进行了MRI检查。使用所开发的方法，为每个参与者构建了胃动力的动态数值几何模型，并给出了相关的几何计算结果。在扫描前摄入了不同组合的固体和液体测试餐。进食状态下胃的容积在0.36 - 1.10升之间。胃模型的平均长度为184至226毫米，最大直径为65至102毫米。从模型和MRI数据计算得到的收缩传播速度吻合良好，约为2毫米/秒。临床相关性——临床医生可从所提出的方法中受益用于诊断目的，因为该方法是半自动的，并且可以提供患者胃动力的动态三维可视化。
