胃动力对食物水解和胃排空的影响：来自计算模型的见解
Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models.
作者信息
Kuhar Sharun, Lee Jae Ho, Seo Jung-Hee, Pasricha Pankaj J, Mittal Rajat
机构信息
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Division of Gastroenterology and Hepatology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Phys Fluids (1994). 2022 Nov;34(11):111909. doi: 10.1063/5.0120933. Epub 2022 Nov 9.
The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.
胃壁的蠕动与消化酶的分泌相结合，启动了分解食物的过程。在本研究中，在人体胃模型中模拟了含有蛋白质的流质食物的混合、分解和排空。在该模型中，负责蛋白质水解的胃酶胃蛋白酶从胃壁近端区域分泌，并使其与胃内容物发生反应。对一个对照案例以及另外三个因糖尿病等病症导致胃动力降低的案例，量化了由蠕动引起的反推射流速度、排空率和水解程度。本研究量化了胃动力对食物分解速率及其排入十二指肠的影响，并将这些观察结果与胃壁运动引起的胃内混合情况相关联。
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