You Jia, Xu Minpeng, Li Rong, Wang Zhongpeng, Liu Shuang, Ming Dong
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2873-2876. doi: 10.1109/EMBC44109.2020.9175356.
Recently, rhythmic visual stimulation (RVS) has been demonstrated to affect the brain function by entraining neural oscillations. However, less is known about how RVS influences the functional connectivity across the whole brain. Here, we applied a graph theoretical approach to analyze the electroencephalography (EEG) connections of 60 nodes when subjects deployed their attention on visual task with different background stimulation, i.e. no background flicker, jittered flicker, and RVS of 6, 10, 15 and 40 Hz, respectively. Thirty-three subjects participated in this study. As a result, the 40-Hz rhythm led to the significantly fastest reaction among all conditions. Furthermore, significantly higher clustering coefficient (C) and small worldness (σ) of θ-band brain network were observed for higher-frequency RVS, which were significantly negatively correlated with reaction time (RT) (C-RT: r =-0.917, p =0.010; σ-RT: r =-0.894, p =0.016). In addition, we found an increase in the connections between dorsolateral prefrontal and visual cortices under RVS compared to no flicker. Our results indicate that RVS can improve the efficiency of brain cortical functional network to facilitate attention.
最近，有研究表明节律性视觉刺激（RVS）通过诱导神经振荡来影响大脑功能。然而，关于RVS如何影响全脑功能连接的了解较少。在此，我们采用一种图论方法，分析了60个节点的脑电图（EEG）连接，这些节点是在受试者分别在无背景闪烁、抖动闪烁以及6Hz、10Hz、15Hz和40Hz的RVS等不同背景刺激下执行视觉任务时所采集的。33名受试者参与了本研究。结果显示，在所有条件中，40Hz节律导致的反应速度显著最快。此外，对于高频RVS，观察到θ波段脑网络的聚类系数（C）和小世界特性（σ）显著更高，且它们与反应时间（RT）显著负相关（C-RT：r = -0.917，p = 0.010；σ-RT：r = -0.894，p = 0.016）。另外，我们发现与无闪烁相比，RVS下背外侧前额叶与视觉皮层之间的连接增加。我们的结果表明，RVS可以提高大脑皮质功能网络的效率以促进注意力。
