Tao Chunling, Shen Xiaoyan, Ma Lei, Li Zhiling, Shen Jiahuan
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:3525-3528. doi: 10.1109/EMBC44109.2020.9175963.
Intraspinal microstimulation is an effective method to rebuild motor function after spinal cord injury. However, in the implementation, available map of stimulation sites is lacking for reference. The location of electrode implantation can only be determined through multiple stimulation, causing secondary damage to the spinal cord. Therefore, in this paper, SD rats were chosen as the research subject, and the intraspinal microstimulation was used to perform three-dimensional scanning electrical stimulation on the lumbar spinal cord that controls the hindlimb motion. The site coordinates and corresponding threshold current that can induce motion of hip, knee and ankle joints were recorded. In order to reduce the individual variances and improve the universality and applicability of the map, the results of 6 groups were normalized, and three-dimensional map of spinal motor function were drawn in the same coordinate system. The overlap of the distribution area of the same motion in each group was defined as the core region. The threshold current of all sites were analyzed statistically to obtain the most appropriate range of current intensity required to induce hindlimb motion. Using appropriate current for intraspinal microstimulation in the core region can selectively induce desired hindlimb motion, greatly improving the accuracy and reliability of electrode implantation.
脊髓内微刺激是脊髓损伤后重建运动功能的一种有效方法。然而，在实施过程中，缺乏可用的刺激位点图谱以供参考。电极植入的位置只能通过多次刺激来确定，这会对脊髓造成二次损伤。因此，本文选取SD大鼠作为研究对象，采用脊髓内微刺激对控制后肢运动的腰段脊髓进行三维扫描电刺激。记录能够诱发髋、膝和踝关节运动的位点坐标及相应阈值电流。为了减少个体差异，提高图谱的通用性和适用性，对6组实验结果进行归一化处理，并在同一坐标系中绘制脊髓运动功能三维图谱。将每组中相同运动分布区域的重叠部分定义为核心区域。对所有位点的阈值电流进行统计分析，以获得诱发后肢运动所需的最合适电流强度范围。在核心区域使用合适的电流进行脊髓内微刺激能够选择性地诱发期望的后肢运动，大大提高了电极植入的准确性和可靠性。
