Shen Xiao-Yan, Tao Chun-Ling, Ma Lei, Shen Jia-Huan, Li Zhi-Ling, Wang Zhi-Gong, Lü Xiao-Ying
School of Information Science and Technology; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
School of Information Science and Technology, Nantong University, Nantong, Jiangsu Province, China.
Neural Regen Res. 2021 Mar;16(3):567-572. doi: 10.4103/1673-5374.293158.
Functional electrical stimulation is an effective way to rebuild hindlimb motor function after spinal cord injury. However, no site map exists to serve as a reference for implanting stimulator electrodes. In this study, rat models of thoracic spinal nerve 9 contusion were established by a heavy-impact method and rat models of T6/8/9 spinal cord injury were established by a transection method. Intraspinal microstimulation was performed to record motion types, site coordinates, and threshold currents induced by stimulation. After transection (complete injury), the core region of hip flexion migrated from the T13 to T12 vertebral segment, and the core region of hip extension migrated from the L1 to T13 vertebral segment. Migration was affected by post-transection time, but not transection segment. Moreover, the longer the post-transection time, the longer the distance of migration. This study provides a reference for spinal electrode implantation after spinal cord injury. This study was approved by the Institutional Animal Care and Use Committee of Nantong University, China (approval No. 20190225-008) on February 26, 2019.
功能性电刺激是脊髓损伤后重建后肢运动功能的有效方法。然而，目前尚无用于指导刺激电极植入的位点图谱。在本研究中，采用重锤撞击法建立胸段第9脊髓神经挫伤大鼠模型，采用横断法建立T6/8/9脊髓损伤大鼠模型。通过脊髓内微刺激记录运动类型、位点坐标和刺激诱发的阈值电流。横断（完全损伤）后，髋关节屈曲的核心区域从第13胸椎节段迁移至第12胸椎节段，髋关节伸展的核心区域从第1腰椎节段迁移至第13胸椎节段。迁移受横断后时间的影响，但不受横断节段的影响。此外，横断后时间越长，迁移距离越长。本研究为脊髓损伤后脊髓电极植入提供了参考。本研究于2019年2月26日获得中国南通大学实验动物管理与使用委员会批准（批准号：20190225-008）。
