Nomoni Michelle, May James M, Kyriacou Panayiotis A
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:4458-4461. doi: 10.1109/EMBC44109.2020.9176476.
This paper introduces a novel technique for the development of custom polydimethylsiloxane (PDMS) vessels for use in phantom technologies. The method involves continuous dip coating of commercial silicone tubes with rapid curation in a single controlled process. The technique accommodates the production of different vessel diameters, wall thicknesses (56 µm-80 µm) and mechanical properties. Clear phantoms were fabricated to compare the commercial silicone tubes against the customs vessels. A pulsatile fluidic pump (BDCLabs, CO, USA) driven by a computer controlled linear motor generated the pulsatile flow through the phantom. The resulting flow profile, using the custom vessels, simulates human blood flow and the detected contact PPG signal from the phantom closely resembles the morphology of in vivo PPG waveforms with signal-to-noise ratios of 38.16 dB and 40.59 dB, compared to the closest commercially-available tubing at 5.38 dB and 10.59 dB for the red and infrared wavelengths respectively. The rigidity and thick walls of commercial silicone tubes impede the expansion of the tubing under systolic pressure. This technique eliminates this common limitation in phantom development.
本文介绍了一种用于开发定制聚二甲基硅氧烷(PDMS)血管以用于体模技术的新技术。该方法包括在单一受控过程中对商用硅胶管进行连续浸涂并快速固化。该技术可生产不同直径、壁厚(56 µm - 80 µm)和机械性能的血管。制造了透明体模以比较商用硅胶管和定制血管。由计算机控制的线性电机驱动的脉动流体泵(BDCLabs,美国科罗拉多州)产生通过体模的脉动流。使用定制血管得到的血流剖面模拟了人体血流,并且从体模检测到的接触式光电容积脉搏波信号(PPG)与体内PPG波形的形态非常相似,红色和红外波长的信噪比分别为38.16 dB和40.59 dB,而最接近的商用管材在红色和红外波长下的信噪比分别为5.38 dB和10.59 dB。商用硅胶管的刚性和厚壁阻碍了管材在收缩压下的扩张。该技术消除了体模开发中的这一常见限制。